Month: November 2022

Jamatia, Ramen; Gupta, Ajay; Pal, Amarta Kumar published an article in 2016, the title of the article was Superparamagnetic Copper Ferrite Nanoparticles Catalyzed One Step Regioselective Synthesis of Dibenzodiazepinones via Ligand and Base Free Ullmann Type Coupling Reaction.Product Details of 99-60-5 And the article contains the following content:

CuFe2O4 superparamagnetic nanoparticles were used as an efficient heterogeneous catalyst for the one-step synthesis of dibenzodiazepinones via Ullmann type coupling reaction. The catalyst was highly stable, efficient and easily synthesized from readily available starting materials. The prepared CuFe2O4 NPs were characterized using various characterization techniques such as TEM, SEM, EDX, XRD, VSM, XPS and FT-IR anal. The thermal stability of the catalyst was also examined by TGA anal. The present methodol. eliminated the multistep procedure for the synthesis of the said compounds The catalyst efficiently catalyzed the reaction under milder condition furnishing high yield of the product within a short reaction time with higher regioselectivity. Furthermore, the CuFe2O4 super paramagnetic nanoparticles were easily separated by an external magnet and reused for four consecutive runs. The present protocol was devoid of any base or ligands and showed excellent result for reproducibility and gram scale reaction which addressing the issues of sustainability and environment friendliness. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Product Details of 99-60-5

The Article related to copper ferrite nanoparticle catalyst preparation, dibenzodiazepinone preparation green chem, chlorobenzoic acid phenylenediamine copper ferrite catalyst regioselective ullmann coupling and other aspects.Product Details of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 30, 2008, Glatthar, Ralf; Carcache, David published a patent.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene The title of the patent was Preparation of benzimidazoles and related compounds as modulators of metabotropic glutamate receptor-5 for treating gastrointestinal, urinary, and nervous system disorders. And the patent contained the following:

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula I (wherein X1 -X4 each independently represent CR2 or N; R2 is H, halo, OH. etc.; R1 is C1-6alkyl, C1-6halogenalkyl, C3-12cycloalkyl, etc.; B is aryl, nitrogen-containing ring, etc.; C is a 5-12-membered aromatic (un)substituted ring system that may contain hetero atoms) and salts, solvates, hydrates and N-oxides thereof. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting 3-chloro-5-iodo-N-2-propylbenzene-1,2-diamine and 5-chloro-6-(6-methylpyridin-3-ylamino)nicotinoyl chloride, caused 97% inhibition of mGluR5 activity at 0.1 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to benzimidazole derivative preparation therapeutic metabotropic glutamate receptor 5 modulator, benzimidazole derivative mglur5 modulator gastrointestinal urinary nervous system disorder and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 23, 2009, Glatthar, Ralf; Carcache, David published a patent.Computed Properties of 38939-88-7 The title of the patent was Preparation of benzimidazoles and related compounds as modulators of metabotropic glutamate receptor-5 for treating gastrointestinal, urinary, and nervous system disorders. And the patent contained the following:

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula I (wherein X1 -X4 each independently represent CR2 or N; R2 is H, halo, OH. etc.; R1 is C1-6alkyl, C1-6halogenalkyl, C3-12cycloalkyl, etc.; B is aryl, nitrogen-containing ring, etc.; C is a 5-12-membered aromatic (un)substituted ring system that may contain hetero atoms) and salts, solvates, hydrates and N-oxides thereof. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting 3-chloro-5-iodo-N-2-propylbenzene-1,2-diamine and 5-chloro-6-(6-methylpyridin-3-ylamino)nicotinoyl chloride, caused 97% inhibition of mGluR5 activity at 0.1 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Computed Properties of 38939-88-7

The Article related to benzimidazole derivative preparation therapeutic metabotropic glutamate receptor 5 modulator, benzimidazole derivative mglur5 modulator gastrointestinal urinary nervous system disorder and other aspects.Computed Properties of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 22, 2018, Boss, Christoph; Corminboeuf, Olivier; Fretz, Heinz; Lyothier, Isabelle; Pozzi, Davide; Richard-Bildstein, Sylvia; Siendt, Herve; Sifferlen, Thierry published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of benzofuran and benzothiophene derivatives as PGE2 receptor modulators. And the patent contained the following:

The title compounds I [R1 = (independently) alkyl, alkoxy, halo, etc.; n = 1-3; R2 =H, alkyl, halo, or cyano; X = S or O; R3 = H, Me or CF3; R41 and R42 = (independently) H, Me; or R41 and R42, together with the carbon atom to which they are attached, represent a cycloprop-1,1-diyl group; R51 and R52 = (independently) H, Me; or R51 and R52, together with the carbon atom to which they are attached, represent a cycloprop-1,1-diyl group; Ar1 = (un)substituted Ph, or 5-6 membered heteroaryl, 8-10 membered bicyclic heteroaryl, etc.] or pharmaceutically acceptable salts thereof, useful in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor, were prepared E.g., a multi-step synthesis of {6-[4-Ethoxy-5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-[2-(5-fluoro-2,7-dimethylbenzo[b]thiophen-3-yl)ethyl]amine, starting from Me 3-ethoxythiophene-2-carboxylate, was described. Exemplified compounds I were evaluated for EP2 and EP4 antagonistic activities (data given). The invention further relates to novel benzofurane and benzothiophene derivatives I and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds I, and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).Category: chlorides-buliding-blocks

The Article related to benzofuran benzothiophene pyrimidinylamino preparation prostaglandin ep2 ep4 receptor antitumor, immune response modulator cancer benzofuran benzothiophene pyrimidinylamino preparation and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2020, Ma, Yichang; Zeng, Jianxian; Zeng, Yajie; Zhou, Hu; Liu, Guoqing; Liu, Yuan; Zeng, Lingwei; Jian, Jian; Yuan, Zhengqiu published an article.Formula: C12H8Cl2O2S The title of the article was Preparation and performance of poly(4-vinylpyridine)-b-polysulfone-b-poly(4-vinylpyridine) triblock copolymer/polysulfone blend membrane for separation of palladium (II) from electroplating wastewaters. And the article contained the following:

In order to sep. palladium (II) from electroplating wastewaters, poly(4-vinylpyridine)-b-polysulfone-b-poly(4-vinylpyridine) (P4VP-PSF-P4VP) / polysulfone blend membranes were fabricated by combining non-solvent induced phase separation, surface segregation and self-assembly of block copolymer. Amphiphilic P4VP-PSF-P4VP was used as the membrane base material, which was synthesized by introducing the functional monomer of 4-vinylpyridine (4-VP), and polysulfone as the additive. Effects of blend ratio and 4-VP content on membrane performance, such as structure, hydrophilicity, pure water flux and adsorption capacity towards Pd (II), were investigated. The membranes exhibited dense surface structure and low roughness due to surface segregation and self-assembly of P4VP-PSF-P4VP. The presence of 4-VP increased hydrophilicity and water flux of membrane, and it also provided good adsorption capacity towards Pd (II) (up to 103.1 ± 5.15 mg/g). Further, the membrane was used to sep. Pd (II) from simulated wastewaters during filtration. It showed good rejection ability and high selectivity towards Pd (II) in co-existence of Cu (II) and Ni (II), and selectivity coefficients of Pd/Cu and Pd/Ni are 41.9 ± 1.88 and 97.8 ± 4.32, resp. In filtration process of actual electroplating wastewater, the membrane also exhibited excellent rejection performance (Pd (II) rejection reached up to 96.8 ± 2.71%). Perhaps it is suitable for future practice applications. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Formula: C12H8Cl2O2S

The Article related to electroplating wastewater palladium adsorption filtration membrane polysulfone triblock copolymer, adsorption membrane, amphiphilic copolymer, electroplating wastewater, palladium (ii) and other aspects.Formula: C12H8Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hossian, Asik; Jana, Ranjan published an article in 2016, the title of the article was Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement.Quality Control of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

We report herein, a silver(I)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, resp., through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen. Mechanistically, the aryl ether moiety undergoes an intramol. ipso attack by the carboxyl radical followed by a C-O or C-S bond cleavage. Aryl-2-mercaptobenzoates undergo oxidative dimerization through a thiol moiety in situ. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid

The Article related to carboxy radical aryl migration smiles rearrangement, aryloxybenzoic arylthiobenzoic acid silver catalyst smiles rearrangement, arylhydroxybenzoate arylmercaptobenzoate dimer preparation and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 20, 1995, Miyamoto, Yoshiko; Kohno, Hitoshi; Pfleiderer, Wolfgang; Boeger, Peter; Wakabayashi, Ko published an article.Application of 452-75-5 The title of the article was Synthesis of 1,2,4-triazolo[1,5-a]-1,3,5-triazine derivatives for phytotoxic activity. And the article contained the following:

Treatment of benzylideneaminoguanidines (I) with Et N-cyanoformimidate (II) in MeCN at room temperature gave 1-benzylideneamino-2-cyanoiminomethylguanidines (III). I (R1 = 2-F and 4-Cl, R2 = H, R3 = Me) and I (R1 = 4-Cl, R2 = H, R3 = Me) were treated with II directly to give 7-methylamino-2-halophenyl-1,2,4-triazolo[1,5-a]-1,3,5-triazines V (R1 = 2-F and 4-Cl, R2 = H, R3 = Me) and V (R1 = 4-Cl, R2 = H, R3 = Me) under similar conditions. III were readily cyclized to the corresponding 1,2-dihydro-1,2,4-triazolo[1,5-a]-1,3,5-triazines (IV) by brief heating in MeOH. IV were oxidized with iodine in EtOH to give the corresponding V. Phytotoxic activities of III, IV, and V were assayed using green microalgae, Scenedesmus acutus. V (R1 = 2-F and 4-Cl, R2 = R3 = H) and some other compounds were found to suppress the cell growth and chlorophyll formation of Scenedesmus, but those activities were still not good enough to be utilized as a herbicide or plant growth regulator. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application of 452-75-5

The Article related to triazolotriazine synthesis phytotoxicity, condensation benzylideneaminoguanidine cyanoformimidate, cyclization benzylideneaminocyanoiminomethylguanidine, oxidation hydrotriazolotriazine and other aspects.Application of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 1993, Nadir, Upender K.; Arora, Anjali published an article.Safety of trimethyloxosulphonium chloride The title of the article was A facile synthesis of N-arylsulfonylazetidines through the reaction of N-arylsulfonylaziridines with dimethyloxosulfonium methylide and a PTC [phase-transfer catalyst]. And the article contained the following:

N-Arylsulfonylazetidines (I; R1 = e.g., H, C6H4Me-p; R2 = alkyl, aryl) can be prepared in 18-55% yield by the reaction of corresponding aziridines (II) with dimethyloxosulfonium methylide in the presence of a PTC (e.g., tetrabutylammonium hydrogen sulfate). Aziridines substituted at positions 2 and 3 failed to react. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Safety of trimethyloxosulphonium chloride

The Article related to ring expansion arylsulfonylaziridine sulfur ylide, aziridine arylsulfonyl ring expansion sulfur ylide, phase transfer ring expansion catalyst arylsulfonylaziridine, azetidine arylsulfonyl and other aspects.Safety of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 31, 1996, Al-Darwich, M. J.; Plenevaux, A.; Lemaire, C.; Fiore, G. D.; Christiaens, L.; Comar, D.; Luxen, A. published an article.Quality Control of 4-Chloro-2-fluorotoluene The title of the article was Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-[18f] fluorophenylalanine. And the article contained the following:

Title compounds I (R = H, Me) were prepared and labeled with no carrier added 18F through a radiochem. synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of 1,3-imidazolidinones II. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatog. (HPLC) purification, with a radiochem. yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F] fluoride. The enantiomeric excesses were ≥97% for both mols. without chiral separation and the radiochem. and chem. purities were ≥98%. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to asym preparation fluorine 18 chlorofluorophenylalanine, phenylalanine chlorofluoromethyl fluorine 18 asym preparation, stereoselective alkylation imidazolidinone chlorofluorobenzyl iodide and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2019, Modha, Sachin G.; Poethig, Alexander; Dreuw, Andreas; Bach, Thorsten published an article.Formula: C11H19ClO2 The title of the article was [6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope. And the article contained the following:

Upon irradiation at λ = 366 nm, tertiary N-alkoxycarbonyl-N-aryl-β-enaminones, e.g., I, furnished exclusively the trans-hexahydrocarbazol-4-ones, e.g., II, by a conrotatory [6π] photocyclization but epimerized on silica to cis-hexahydrocarbazol-4-ones, e.g., III (14 examples, 44-98% yield). The acceptor substitution on the nitrogen atom enhanced the stability of the cyclized products compared to N-alkyl-N-aryl-β-enaminones reported previously. The mechanism of the [6π] photocyclization was investigated by quenching experiments, deuterium-labeling experiments, and DFT calculations, suggesting a triplet pathway for the conrotatory ring closure followed by a suprafacial [1,4] hydrogen migration. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to cis hexahydrocarbazolone preparation intramol diastereoselective photocyclization alkoxycarbonylarylenaminone, hexahydrocarbazolone cis trans epimerization mechanistic study dft homo lumo and other aspects.Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics