Month: November 2022

Chen, Xiulei; Zhou, Zhen; Li, Zhong; Xu, Xiaoyong published an article in 2020, the title of the article was Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita.Synthetic Route of 89-77-0 And the article contains the following content:

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO2, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO2, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to benzotriazinone dihydrothiazole thiol preparation nematocidal activity, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 11, 1993, Cantegril, Richard; Croisat, Denis; Desbordes, Philippe; Guigues, Francois; Mortier, Jacques; Peignier, Raymond; Vors, Jean Pierre published a patent.Formula: C7H6ClF The title of the patent was Fungicidal arylpyrazoles and their preparation, compositions, and use. And the patent contained the following:

The invention relates to new derivatives of the family of 3-arylpyrazoles, their methods of preparation, compositions containing them, and their utilization for the protection of plants against fungal diseases. The invention relates more particularly to 3-arylpyrazole derivatives having the formula I [X1-X5 = H, halo, OH, cyano, NO2, alkyl, amino, etc.; or 2 adjacent X may form carbon chain with optional heteroatoms or substituents; Y = H, halo, NO2, cyano, alkoxy, amino, etc.; Z = H, halo, cyano, OH, NO2, alkoxy, alkylthio, amino, C(Z1)Z2, etc.; Z1 = O, S, alkylamino, imino, arylamino; Z2 = H, halo, OH, SH, cyano, amino, alkyl, alkoxy, etc.]. For example, condensation of 3,5-dichloroacetophenone with DMF di-Me acetal gave 77% 3,5-Cl2C6H3COCH:CHNMe2, which was cyclized with hydrazine hydrate in EtOH give 90% 3-(3,5-dichlorophenyl)-1H-pyrazole (II; Y = H). Chlorination of this with N-chlorosuccinimide in CH2Cl2 gave 57% II (Y = Cl), which as a 1-g/L suspension gave good (≥75%) protection of tomato leaves from Botrytis cinerea. Over 330 compounds, including products and/or intermediates, were prepared Addnl. tests and formulations are described. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to arylpyrazole preparation fungicide, pyrazole aryl preparation fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Prech, Jan; Matousek, Vacla; Vaclavik, Jiri; Pechacek, Jan; Syslova, Kamila; Sot, Petr; Januscak, Jakub; Vilhanova, Beata; Kuzma, Marek; Toman, Jaromir; Kacer, Petr published an article in 2013, the title of the article was Determination of enantiomeric composition of substituted tetrahydroisoquinolines based on derivatization with menthyl chloroformate.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

A method for the anal. of the optical purity of a series of chiral substituted tetrahydroisoquinolines (THIQs) was developed. The method is based on pre-column derivatization of the analytes with the derivatization reagent (-)-(1R)-menthyl chloroformate. The derivatization reaction selectively gives diastereomeric carbamates that are resolvable on an achiral non-polar GC column. The developed technique covers variously substituted THIQs, which differ significantly in volatility, steric and electronic properties. In all cases, the resolution factors (R) exceeded the value of 1.5. The method represents a robust way of anal. of mixtures of THIQs, which are often present in various matrixes such as body fluids, tissues and reaction mixtures The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to enantiomer tetrahydroisoquinoline menthyl chloroformate derivatization gc ei ms, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 12, 2008, Johnson, Christopher Norbert; Jones, David G.; Liang, Xi; Macpherson, David Timothy; Miller, Aaron B.; Naylor, Antoinette; Stanway, Steven James; Takle, Andrew Kenneth; Trani, Giancarlo published a patent.Related Products of 1056264-66-4 The title of the patent was Indazole derivatives as estrogen receptor beta mediators and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention relates to indazole derivatives of formula I which have pharmacol. activities, to processes for their preparation, to compositions containing them and to uses of these compounds in the treatment of estrogen receptor beta (ER-β) mediated diseases. Compounds of formula I wherein Ra, Rb and Rc are independently halo, C1-4 alkoxy, C1-4 alkyl, C2-4 alkenyl, C1-5 alkanoyl, CF3, CF3O and CN; provided that when one of the substitutes is attached to the C-5 of the indazole bicycle, this substituent Ra is not methoxy; m is 0-3; n is 0-1; p is 0-4; m, n and p together is ≤ 5; and their pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by debenzylation of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole. All the invention compounds were evaluated for their ER-β receptor binding ability. From the assay, it was determined that II and other tested compounds exhibited the pIC50 value of > 7. The experimental process involved the reaction of 2-Bromo-3-chloro-6-fluorobenzaldehyde(cas: 1056264-66-4).Related Products of 1056264-66-4

The Article related to indazole derivative preparation estrogen receptor mediator receptor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 1056264-66-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 6, 2006, Brohm, Dirk; Diedrichs, Nicole; Huebsch, Walter; Schneider, Dirk; Froehlen, Britta-Nicole; Gerdes, Christoph; Gnoth, Mark Jean; Perzborn, Elisabeth; Voehringer, Verena published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of azetidinylpyrazolines as anticoagulation agents. And the patent contained the following:

Title compounds I [X = (CH2)m; m = 0-3; Y = (CH2)n; n = 0-3; R1 = tetramic acid, NR5R6, etc.; R2 = Me, cycloalkyl, Ph, etc.; R3 = substituted Ph, thienyl; A = bond, O; R5 = H, Me, Et, etc.; R6 = H, Me, Et, etc.] and their pharmaceutically acceptable salts and formulations were prepared For example, N-acylation of 3-propylazetidine with phenol ester II afforded azetidinylpyrazoline III in 72% yield. In protease activated receptor 1 assays, 6-examples of compounds I exhibited IC50 values ranging from 14-395 nM. The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Category: chlorides-buliding-blocks

The Article related to azetidinylpyrazoline preparation protease activated receptor par1 anticoagulation agent, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 5, 1978, Henrick, Clive A.; Garcia, Barbara A. published a patent.Product Details of 452-75-5 The title of the patent was Amino acid esters and thiol esters. And the patent contained the following:

RR1NCR2R3COXR4 [R = cycloalkyl, cycloalkenyl, substituted Ph; R1 = H, alkyl, haloalkylcarbonyl, HCO; R2 = C2-5-alkyl, C2-5-alkenyl, C1-4-haloalkyl, C2-4-haloalkenyl, C3-4-cycloalkyl; R3 = H, F; X = O, S; R4 = CHR5R6 [R5 = H, CN, Me, CF3, CCH, CSNH2; R6 = substituted Ph, Q (R8 = H, alkyl; R9 = alkenyl, alkynyl, aralkyl; X1 = O, S)], CH2R10 [R10 = Q1 (R12R13 = alkylene, alkenylene; X2 = O, S), Q2 (R15 = H, alkyl, alkenyl, alkynyl, aralkyl; R16 = H, alkyl)], CH2CR17:CR18CH2R19 (R17 and R18 = H, Cl, F, Me; R17R18 = bond; R19 = Ph, OPh), CH(CCH)CR20:CHR21 (R20 = H, halo, Me, Et; R21 = allyl, propargyl, 3-butenyl, 3-butynyl, Ph, CH2Ph)] and their salts were prepared as pesticides. Thus, Me2CHCHBrCO2H was treated with SOCl2 to give the acid chloride, which was esterified with HOCH2C6H4OPh-m to give Me2CHCHBrCO2CH2C6H4OPh-m, which was aminated with PhNH2 to give PhNHCH(CHMe2)CO2CH2C6H4OPh-m. A great number of other N-substituted valine esters were also prepared Pesticide activity data are given. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5

The Article related to amino acid ester, pesticide amino acid ester, thioester amino acid, valine ester preparation pesticide, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 22, 2022, Thorat, Vijaykumar H.; Tsai, Yu-Lin; Huang, Yong-Ran; Cheng, Chien-Hong; Hsieh, Jen-Chieh published an article.Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride The title of the article was Nickel-Catalyzed Denitrogenative Cyclization of 1,2,3,4-Benzothiatriazin-1,1(2H)-dioxides with Arynes To Synthesize Biaryl Sultams. And the article contained the following:

The nickel-catalyzed denitrogenative cyclization reaction of 1,2,3,4-benzothiatriazine-1,1-dioxides with arynes to generate the polysubstituted biaryl sultams with tolerance of a wide diversity of substituents on every subunit was reported. The mechanistic study indicated that the reaction was initiated by the formation of a diradical species, which reacted with a nickel complex to form a nickelacycle intermediate and carried out the subsequent cyclization through insertion of an aryne. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to biaryl fuse sultam preparation, benzothiatriazine aryne nickel catalyst denitrogenative heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 8, 2022, Li, Xuan; Chen, Mengnan; Xie, Chuan; Zhang, Jing published an article.Application of 80-07-9 The title of the article was Visible light-activated ruthenium-catalyzed direct arylation at ambient temperature. And the article contained the following:

A visible light-activated ruthenium-catalyzed direct arylation of aryl C-H bonds 1-R-2-R1-3-R2-4-R3C6H2 (R = 5-methyl-1H-pyrazol-1-yl, isoquinolin-1-yl, 1H-indazol-1-yl, etc.; R1 = H, OMe, Me, F; R2 = H, Me, Ph, CF3, C(O)Me, C(O)OMe; R1 R2 = -CH=CH-CH=CH-; R3 = H, Me, OMe, CF3, Cl, C(O)OMe; R2 R3 = -CH=CH-CH=CH-) with aryl (pseudo)halides R4X (R4 = Ph, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; X = I, Cl, Br, OTf), which operates at ambient temperature with broad substrate scopes and excellent compatibility of functionalities was presented. The key to success of this strategy is the efficient generation of active catalytic species via photo-induced ligand dissociation The choices of the bases and solvents also have significant influence on the catalytic efficiency. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Application of 80-07-9

The Article related to biphenylpyrazole preparation chemoselective photochem, phenylpyrazole aryl halide arylation ruthenium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2021, Polina, Saibabu; Putta, V. P. Rama Kishore; Gujjarappa, Raghuram; Singh, Virender; Pujar, Prasad Pralhad; Malakar, Chandi C. published an article.Application of 89-77-0 The title of the article was P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol Towards the Synthesis of N,S-Heterocycles and Spiro Compounds. And the article contained the following:

A P(III)-mediated entry towards construction of C-N/C-S bond has been devised. The developed heterocyclization method was applied to the synthesis of a diverse range of N,S-heterocycles and related spiro mols. P(NMe2)3 showed the maximum efficacies under the aerobic reaction conditions, and a range of bis-nucleophiles and isothiocyanates were tolerated well to serve the access of manifold immense mols. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to isothiocyanate amine heterocyclization phosphine mediated, thiazine benzothiazine thiazole preparation, spiro heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2022, Clemens, Jennifer; Bell, Emily L.; Londregan, Allyn T. published an article.Product Details of 98946-18-0 The title of the article was Selective N2-Alkylation of 1H-Indazoles and 1H-Azaindazoles. And the article contained the following:

A general and selective procedure for the N2-alkylation of 1H-indazoles and 1H-azaindazoles is presented. Promoted by either trifluoromethanesulfonic acid or copper(II) triflate, diverse 1H-indazoles/azaindazoles are selectively alkylated with varied primary, secondary, and tertiary alkyl 2,2,2-trichloroacetimidates at the N2-nitrogen to afford the corresponding 2-alkyl-2H-indazoles/azaindazoles. Forty-one examples are included along with a discussion of reaction optimization, scope, and mechanism. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to alkyl indazole azaindazole preparation regioselective, indazole azaindazole primary secondary tertiary alkyl trichloroacetimidate alkylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics