Month: November 2022

Ding, Shunmin; Cheng, Dan; Xiao, Weiming; Ma, Xiaohua; Zeng, Rong; Liu, Senqun; Liang, Sanqi; Chen, Chao; Song, Wei-Guo published an article in , the title of the article was Nickel Nanoparticles Encapsulated in Carbon Nanotubes as an Efficient and Robust Catalyst for Hydrogenation of Nitroarenes.Reference of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

Catalytic hydrogenation of nitroarenes is an efficient and commonly used route for preparing aromatic amines. The cost-effective metallic Ni catalyst prefers to be used for its superior hydrogenation activity, but they generally are not stable enough and usually show poor reusability. In this work, carbon nanotube encapsulating metallic Ni catalysts were prepared by simple ball milling and calcining the mixture of poss-octaphenyl and nickel (II) acetate tetrahydrate. The as-prepared metallic nickel encapsulated catalyst Ni@CNT-800 exhibited excellent stability in the hydrogenation reaction, no any activity decrease was observed after ten runs whether at high conversion or low conversion. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Reference of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to nickel carbon nanotube hydrogenation activation energy stability, Placeholder for records without volume info and other aspects.Reference of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 30, 2021, Soraggi Battagin, Tiago; Nicolas Caccalano, Mario; Dilarri, Guilherme; Felipe Cavicchia Zamuner, Caio; Alleoni, Natalia; Leonardo Saldanha, Luiz; Bacci, Mauricio Jr.; Ferreira, Henrique published an article.Application of 35444-44-1 The title of the article was Syzygium aromaticum (clove) essential oil: An alternative for the sanitization of citrus fruit in packinghouses. And the article contained the following:

Citrus canker is a quarentenary disease caused by Xanthomonas citri subsp. citri (X. citri). Thus, sanitization of fresh fruit is a necessary measure before any com. activity. Therefore, we evaluated the clove essential oil (CEO), as an alternative sanitizer for the disinfection of citrus fruit in packinghouses. Tests in vitro and in vivo were carried out to determine the cell inhibitory concentration and to verify the efficacy of the oil for the disinfection of citrus fruits. In in vitro tests, CEO was able to inhibit X. citri when used at 0.75% (volume/volume). In experiments that simulate the sanitization process used in packinghouses, 5% CEO was as effective as the recommended sanitization product based on sodium hypochlorite. GC-MS results showed a high presence of eugenol derivatives as the major compounds of CEO. All results proved that CEO is a potential sanitizer that could be used as an alternative to sodium hypochlorite. Novelty impact statement : Exptl. evidence shows that the clove essential oil (CEO) has the same sanitization efficacy as sodium hypochlorite, which makes of CEO an alternative sanitizer for the decontamination of citrus fruits to be exported to the European Union. CEO is a safer and more sustainable sanitizer for the postharvest disinfection of citrus fruit. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to syzygium aromaticum essential oil citrus fruit packing sanitization, Placeholder for records without volume info and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 25, 2022, Ochi, Akihiro; Yoritate, Makoto; Miyamoto, Tomofumi; Usui, Kazuteru; Yusakul, Gorawit; Putalun, Waraporn; Tanaka, Hiroyuki; Hirai, Go; Morimoto, Satoshi; Sakamoto, Seiichi published an article.Application In Synthesis of tert-Butyl trichloroacetimidate The title of the article was Harringtonine Ester Derivatives with Enhanced Antiproliferative Activities against HL-60 and HeLa Cells. And the article contained the following:

Harringtonine (HT), produced from Cephalotaxus species, is known to exhibit potent antiproliferative activity against myeloid leukemia cells by inhibiting protein synthesis. A previous study using acute promyelocytic leukemia (HL-60) cells raised the possibility that the C-5′ Me group of HT plays an important role in regulating leukemia cell line antiproliferative activity. In order to investigate the effect of hydrocarbon chains at C-5′ on the resultant activity, the C-5′ Me group was replaced with various straight- and branched-chain hydrocarbons using the corresponding alcs., and their antiproliferative activity against HL-60 and HeLa cells was investigated. As a result, 4′-n-heptyl-4′-demethylharringtonine (1f, n-heptyl derivative)(I) showed the most potent cytotoxicity among the HT ester derivatives produced, with IC50 values of 9.4 nM and 0.4 μM for HL-60 and HeLa cells, resp. Interestingly, the cytotoxicity of derivative 1f against HL-60 and HeLa cells resp. was ~5 (IC50 = 50.5 nM) and ~10 times (IC50 = 4.0 μM) those of HT and ~2 (IC50 = 21.8 nM) and ~4 times (IC50 = 1.7 μM) more than homoharringtonine (HHT). These results demonstrate the potential of the derivative 1f as a lead compound against leukemia. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate

The Article related to harringtonine ester derivative antiproliferative leukemia cephalotaxus, Placeholder for records without volume info and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rosenbach, Dominic; Krimalowski, Alexander; Erabhoina, Harimohan; Thelakkat, Mukundan published an article in 2022, the title of the article was Solid polymer electrolytes from polyesters with diester sidechains for lithium metal batteries.Formula: C7H11ClO3 And the article contains the following content:

A series of polymethacrylates and polyacrylates carrying diester side chain moieties with varying alkyl spacer lengths are designed, synthesized, and evaluated as solid polymer electrolytes (SPEs) in lithium metal batteries (LMBs). These amorphous polymers with glass transition temperatures in the range of -58 to +32 °C are tested as SPEs in combination with LiTFSI or LiFSI. At an optimum salt concentration of 25 wt%, ionic conductivities up to 10-4 S cm-1 at 70 °C are achieved. These SPEs reveal high lithium transport numbers (0.5-0.7) and high electrochem. stability (5.4 V vs. Li/Li+) as determined by LSV. In combination with an ultrathin polyimide membrane and 10 wt% TiO2 nanoparticles, dendrite-free plating/stripping at 40 and 70 °C is realized in sym. Li|SPE|Li cells. Detailed extended distribution of relaxation times (eDRT) anal. of impedance measurements is employed for understanding the diverse cell processes. In solvent-free LMBs comprising a polyimide membrane soaked with the nanocomposite polyester electrolyte, lithium metal foil as the anode and an optimized LiFePO4 cathode, a very high initial specific discharge capacity of 152 mA h g- 1 (at 0.2C, 70 °C), excellent capacity retention of 94% after 100 cycles (at 1C, 70 °C) and negligible capacity fading even at 2C (96% retention after 300 cycles) are demonstrated. These novel polyester-based SPEs exhibit high cycling stability at 40 °C, making them highly attractive for room temperature applications. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Formula: C7H11ClO3

The Article related to titanium oxide polyester solid polymer electrolyte lithium metal battery, Placeholder for records without volume info and other aspects.Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 10, 2019, Hobbs, Heather; Bravi, Gianpaolo; Campbell, Ian; Convery, Maire; Davies, Hannah; Inglis, Graham; Pal, Sandeep; Peace, Simon; Redmond, Joanna; Summers, Declan published an article.Safety of trimethyloxosulphonium chloride The title of the article was Correction to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway [Erratum to document cited in CA171:311735]. And the article contained the following:

There are errors in Figures 4 and 5 as well as the corresponding article and Supporting Information text; the corrections are provided here. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Safety of trimethyloxosulphonium chloride

The Article related to morpholine isostere pi3k akt mtor pathway inhibitor conformation erratum, Placeholder for records without volume info and other aspects.Safety of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 15, 2021, Abdulwahab, Muhammad Kumayl; Tan, Ke Han; Dzulkeflee, Rashidi; Leong, Kok Hoong; Heh, Choon Han; Ariffin, Azhar published an article.Safety of 2-Amino-4-chlorobenzoic acid The title of the article was In-silico Studies of the Antiproliferative Activity of New Anilinoquinazoline Derivatives Against NSCLC Cells.. And the article contained the following:

The current reversible epidermal growth factor (EGFR) tyrosine kinase inhibitors of non-small cell lung cancer (NSCLC) have been resisted by T790M mutation, while the irreversible inhibitors introduced to overcome the mutation have faced resistance from C979S mutation. In the effort to discover potentially improved reversible EGFR inhibitors, a series of new anilinoquinazoline derivatives with modification on the 2nd carbon on the aniline ring was synthesized. The derivatives were tested for their antiproliferative activity against NSCLC cell lines with wild-type (A549), exon 19 deletion mutated (H1650) and L858R+T790M (H1975) mutated EGFR kinases. Three derivatives (4-6) performed better than the standard drug, gefitinib, in all cell lines. Derivative 5 recorded the lowest IC50 values in all cell lines (A549: 24.60 ± 0.75 μM, H1650: 14.83 ± 0.54 μM, H1975: 21.72 ± 1.21 μM). A mol. docking study followed by mol. dynamics simulations was performed on derivative 5 and gefitinib using wild-type EGFR kinase (WT-EGFR) and L858R+T790M mutated kinase (LRTM-EGFR) to provide an understanding of their binding mechanisms. In WT-EGFR kinase, derivative 5 recorded better hydrogen bonding occupancy with MET793 (94.16%) and binding energy profile (-35.287 kcal/mol) as compared to gefitinib (91.80%, -26.071 kcal/mol). In LRTM-EGFR kinase, derivative 5 recorded better hydrogen bonding occupancy with MET793 (93.68%) as compared to gefitinib (91.48%). Derivative 5 also recorded addnl. hydrogen bonding interactions with ASP855, with a total of 60.61% occupancy as well as a better energy profile (-42.867 kcal/mol) as compared to gefitinib (-41.778 kcal/mol). The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Safety of 2-Amino-4-chlorobenzoic acid

The Article related to anilinoquinazolin antiproliferative activity kinase inhibitor mol docking, Placeholder for records without volume info and other aspects.Safety of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nakashima, Kazuma; Iikuni, Shimpei; Watanabe, Hiroyuki; Ono, Masahiro published an article in 2021, the title of the article was Development of a novel radiotheranostic platform with a DOTA-based trifunctional chelating agent.Computed Properties of 98946-18-0 And the article contains the following content:

Radiotheranostics has attracted attention as a powerful strategy for treating cancer patients with precision medicine. We designed and synthesized a novel DOTA-based trifunctional agent, ADIBO-DOTADG-ALB (ADA), which allowed compounds with targeting ligands, radiometals, and an albumin binder to be readily prepared ADA exhibited promising properties as a theranostic platform. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Computed Properties of 98946-18-0

The Article related to dota based trifunctional indium labeled chelation complex radiotheranostic, Placeholder for records without volume info and other aspects.Computed Properties of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 19, 2022, Sabbah, Dima A.; Samarat, Hla H.; Al-Shalabi, Eveen; Bardaweel, Sanaa K.; Hajjo, Rima; Sweidan, Kamal; Khalaf, Reema Abu; Al-Zuheiri, Aya M.; Abushaikha, Ghassan published an article.Name: 2-Amino-4-chlorobenzoic acid The title of the article was Design, Synthesis, and Biological Examination of N-Phenyl-6-fluoro-4-hydroxy-2-quinolone-3-carboxamides as Anticancer Agents. And the article contained the following:

Cancer is one of the leading causes of death worldwide, and it has a major impact on public health. Phosphatidylinositol 3-kinase (PI3Kα) has been recognized as a promising drug target for developing anticancer agents. Herein, a series of N-phenyl-6-fluoro-4-hydroxy-2-quinolone-3-carboxamides was developed to target PI3Kα. All synthesized compounds were characterized using FT-IR, NMR (1H and 13C) and elemental anal. All synthesized chem. analogs exerted distinctive anticancer activity. They inhibited the growth of human epithelial colorectal adenocarcinoma (Caco-2) with IC50 values between 48.63-378 μM, and human colon cancer (HCT-116) cell lines with IC50 values between 44-664 μM. Computational modeling studies provided important biol. insight. Induced-fit docking (IFD) studies showed that the synthesized chem. analogs fit the kinase catalytic domains and form a significant H-bond interaction network with key amino acids at the biding site. Furthermore, cheminformatics analyses indicated that all synthesized compounds were drug-like permitting further animal testing or clin. development. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid

The Article related to phenylfluoro hydroxyquinolone carboxamide anticancer agent clin development, Placeholder for records without volume info and other aspects.Name: 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shimodaira, Shingo; Iwaoka, Michio published an article in 2019, the title of the article was Synthesis of selenocysteine-containing dipeptides modeling the active site of thioredoxin reductase.Synthetic Route of 98946-18-0 And the article contains the following content:

Four cyclic dipeptides modeling the active site of thioredoxin reductase (TrxR), UU, CU, UC, and CC, where U and C represent selenocystine and cystine, resp., were synthesized and their glutathione peroxidase (GPx)-like catalytic activity was evaluated by the reaction of hydrogen peroxide (H2O2) with glutathione (GSH) in the presence of glutathione reductase (GR). Among these, only UC exhibited the significant antioxidant capacity, suggesting that an at. environment around the Se-S bond is relevant to the reactivity toward a thiol substrate. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Synthetic Route of 98946-18-0

The Article related to thioredoxin reductase trxr active site mimic cyclic dipeptide selenocysteine, Enzymes: Structure-Conformation-Active Site and other aspects.Synthetic Route of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yao, Si; Zheng, Yunman; Jiang, Lijun; Xie, Chen; Wu, Fengshou; Huang, Chi; Zhang, Xiong; Wong, Ka-Leung; Li, Zaoying; Wang, Kai published an article in 2018, the title of the article was Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study.Synthetic Route of 4569-86-2 And the article contains the following content:

A methylene violet 3RAX-conjugated porphyrin has been designed and synthesized as a potential photosensitizer in photodynamic therapy because of its high DNA binding constant and the efficacy in inhibiting cancer cells with subcellular localization. At 400μM, the DNA photocleavage activities of compound 1 and2 were 80% and 20%, resp. The results fromphotophys. studies and cell experiments suggest porphyrin-methylene violet 3RAX conjugate could be developed as potential photosensitizers for mitochondrial targeting action in PDT. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Synthetic Route of 4569-86-2

The Article related to methylene violet 3rax dna photocleavage photosensitizer photodynamic therapy, Placeholder for records without volume info and other aspects.Synthetic Route of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics