Month: November 2022

On December 9, 2010, Bovens, Stefanie; Schulze Elfringhoff, Alwine; Kaptur, Martina; Reinhardt, Dirk; Schafers, Michael; Lehr, Matthias published an article.Application In Synthesis of Methyl 6-chloro-6-oxohexanoate The title of the article was 1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A2α: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability. And the article contained the following:

Indole-5-carboxylic acids with 3-aryloxy-2-oxopropyl residues in position 1 have been found to be potent inhibitors of human cytosolic phospholipase A2α (cPLA2α). In the course of structure-activity relationship studies, we investigated the effect of a substitution of indole 3 position with acyl, alkyl, and oxadiazole residues. The highest increase of inhibitory potency could be achieved by a 3-methyl-1,2,4-oxadiazol-5-yl-moiety. Appropriate compound 40 revealed an IC50 of 0.0021 μM against isolated cPLA2α. In a cellular assay applying human platelets 40 blocked cPLA2α activity even with an IC50 of 0.0006 μM. Metabolic stability and aqueous solubility of the target compounds were also determined Furthermore, one selected compound was tested for peroral bioavailability in mice. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application In Synthesis of Methyl 6-chloro-6-oxohexanoate

The Article related to carboxyindolyl propanone inhibitor cpla preparation structure stability solubility bioavailability, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of Methyl 6-chloro-6-oxohexanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 15, 2016, Cui, Zhishan; Li, Xi; Li, Lulu; Zhang, Bin; Gao, Chunmei; Chen, Yuzong; Tan, Chunyan; Liu, Hongxia; Xie, Weiyi; Yang, Ti; Jiang, Yuyang published an article.Related Products of 99-60-5 The title of the article was Design, synthesis and evaluation of acridine derivatives as multi-target Src and MEK kinase inhibitors for anti-tumor treatment. And the article contained the following:

Clin. studies have shown enhanced anticancer effects of combined inhibition of Src and MEK kinases. Development of multi-target drugs against Src and MEK is of potential therapeutic advantage against cancers. As a follow-up of our previous studies, and by using mol. docking method, we designed and synthesized a new series of 9-anilinoacridines containing phenyl-urea moieties as potential novel dual Src and MEK inhibitors. The anti-proliferative assays against K562 and HepG-2 tumor cells showed that most of the derivatives displayed good cytotoxicity in vitro. In particular, kinase inhibition assays showed that compound 8m inhibited Src (59.67%) and MEK (43.23%) at 10 μM, and displayed moderate inhibitory activity against ERK and AKT, the downstream effectors of both Src and MEK. Moreover, compound 8m was found to induce K562 cells apoptosis. Structure-activity relationships of these derivatives were analyzed. Our study suggested that acridine scaffold, particularly compound 8m, is of potential interest for developing novel multi-target Src and MEK kinase inhibitors. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5

The Article related to acridine derivative preparation src mek kinase inhibitor cancer, acridine, antitumor, apoptosis, kinase inhibitor, mek, src, Pharmacology: Structure-Activity and other aspects.Related Products of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 1, 2015, Song, Kebiao; Xu, Xing; Liu, Peng; Chen, Lili; Shen, Xu; Liu, Junhua; Hu, Lihong published an article.Related Products of 99-60-5 The title of the article was Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists. And the article contained the following:

3-(Tert-Butyl)-4-hydroxyphenyl 2,4-dichlorobenzoate (1) was discovered in our inhouse high throughput screening as a moderate FXR antagonist. To improve the potency and the stability of the hit 1, forty derivatives were synthesized and SAR was systematically explored. The results turn out that replacing the 2,4-dichlorophenyl with 2,6-dichloro-4-amidophenyl shows great improvement in potency, replacing the benzoate with benzamide shows improvement in stability and slight declining of potency and 3-(tert-butyl)-4-hydroxyphenyl unit is essential in obtaining the FXR antagonistic activity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5

The Article related to farnesoid fxr antagonist benzoate benzamide derivative preparation structure activity, fxr, fxr antagonist, non-steroidal, sar study, Pharmacology: Structure-Activity and other aspects.Related Products of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Budke, Brian; Tueckmantel, Werner; Miles, Kelsey; Kozikowski, Alan P.; Connell, Philip P. published an article in 2019, the title of the article was Optimization of drug candidates that inhibit the D-loop activity of RAD51.Safety of tert-Butyl trichloroacetimidate And the article contains the following content:

RAD51 is the central protein in homologous recombination (HR) repair, where it first binds ssDNA and then catalyzes strand invasion via a D-loop intermediate. Addnl., RAD51 plays a role in faithful DNA replication by protecting stalled replication forks; this requires RAD51 to bind DNA but may not require the strand invasion activity of RAD51. We previously described a small-mol. inhibitor of RAD51 named RI(dl)-2 (RAD51 inhibitor of D-loop formation #2, hereafter called 2h(I)), which inhibits D-loop activity while sparing ssDNA binding. However, I is limited in its ability to inhibit HR in vivo, preventing only about 50 % of total HR events in cells. We sought to improve upon this by performing a structure-activity relationship (SAR) campaign for more potent analogs of I. Most compounds were prepared from 1-(2-aminophenyl)pyrroles by forming the quinoxaline moiety either by condensation with aldehydes, then dehydrogenation of the resulting 4,5-dihydro intermediates, or by condensation with N,N’-carbonyldiimidazole, chlorination, and installation of the 4-substituent through Suzuki-Miyaura coupling. Many analogs exhibited enhanced activity against human RAD51, but in several of these compounds the increased inhibition was due to the introduction of dsDNA intercalation activity. We developed a sensitive assay to measure dsDNA intercalation, and identified two analogs of I that promote complete HR inhibition in cells while exerting minimal intercalation activity. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to rad51 d loop homologous recombination quinoxaline, dna repair, biological activity, cancer, inhibitors, structure-activity relationships, Pharmacology: Structure-Activity and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 20, 2015, Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene; Qian, Weixing; Nguyen Tran, Nam Phuong; Kindahl, Tomas; Svensson, Richard; Saar, Valeria; Artursson, Per; Olivecrona, Gunilla; Enquist, Per-Anders; Elofsson, Mikael published an article.Recommanded Product: 99-60-5 The title of the article was Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo. And the article contained the following:

The risk of cardiovascular events increases in individuals with elevated plasma triglyceride (TG) levels, therefore advocating the need for efficient TG-lowering drugs. In the blood circulation, TG levels are regulated by lipoprotein lipase (LPL), an unstable enzyme that is only active as a non-covalently associated homodimer. We recently reported on a N-phenylphthalimide derivative (1) that stabilizes LPL in vitro, and moderately lowers triglycerides in vivo (Biochem. Biophys. Res. Commun.2014, 450, 1063). Herein, we establish structure-activity relationships of 51 N-phenylphthalimide analogs of the screening hit 1. In vitro evaluation highlighted that modifications on the phthalimide moiety were not tolerated and that lipophilic substituents on the central Ph ring were functionally essential. The substitution pattern on the central Ph ring also proved important to stabilize LPL. However, in vitro testing demonstrated rapid degradation of the phthalimide fragment in plasma which was addressed by replacing the phthalimide scaffold with other heterocyclic fragments. The in vitro potency was retained or improved and substance 80 proved stable in plasma and efficiently lowered plasma TGs in vivo. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to structure preparation lipoprotein lipase agonist triglyceride, agonist, lpl, lipoprotein lipase, structure–activity relationship, triglyceride, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaur, Avneet; Pathak, Dharam P.; Sharma, Vidushi; Wakode, Sharad published an article in 2018, the title of the article was Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents.Recommanded Product: 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 μM) were evaluated in vivo for their anti-inflammatory potential by the carrageenan-induced rat paw edema method. Out of 13 newly synthesized compounds, six compounds were found to be the most potent COX-2 inhibitors in the in vitro enzymic assay, with IC50 values in the range of 0.06-0.71 μM. The in vivo anti-inflammatory activity of these compounds was assessed by the carrageenan-induced rat paw edema method. Compounds I (84.09%), II (79.54%), and III (70.45%) demonstrated significant anti-inflammatory activity compared to the standard drug ibuprofen (65.90%) and were also found to be safer than ibuprofen, by ulcerogenic studies. A docking study was done using the crystal structure of human COX-2, to understand the binding mechanism of these inhibitors to the active site of COX-2. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 2-Chloro-4-nitrobenzoic acid

The Article related to docking cox2 inhibitor antiinflammatory inflammation, cox-1, cox-2, n-(3,5-dimethoxphenyl)-benzoxazole, anti-inflammatory activity, ulcerogenic activity, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 1, 2014, Yang, Wei; Li, Lixuan; Ji, Xun; Wu, Xiaowei; Su, Mingbo; Sheng, Li; Zang, Yi; Li, Jia; Liu, Hong published an article.Formula: C7H11ClO3 The title of the article was Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. And the article contained the following:

A series of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel HDACs inhibitors were designed, synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDAC1, 3, 6. The IC50 values of compound 10r against HDAC1, HDAC3, HDAC6 was 1.14 ± 0.03 nM, 3.56 ± 0.08 nM, 11.43 ± 0.12 nM. Compound 10r noticeably up-regulated the level of histone H3 acetylation compared to the SAHA. Most of the compounds showed the strong anti-proliferative activity against human cancer cell lines including RMPI8226 and HCT-116. The IC50 values of Compounds 10r and 10t against RPMI8226 was 2.39 ± 0.20 μM, 1.41 ± 0.44 μM, resp., and the HCT-116 was sensitive to the compounds 10h, 10m, 10r, 10w with the IC50 values <1.9 μM. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Formula: C7H11ClO3

The Article related to anilinothieno pyrimidine hydroxamate derivative preparation histone deacetylase inhibitor cancer, hdacs, hdacs inhibitor, hydroxamic acid, thieno[2,3-d]pyrimidines, Pharmacology: Structure-Activity and other aspects.Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fancellu, Gaia; Chand, Karam; Tomas, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Silvia; Santos, M. Amelia published an article in 2020, the title of the article was Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease.Application In Synthesis of 2-Amino-4-chlorobenzoic acid And the article contains the following content:

Pursuing the widespread interest on multi-target drugs to combat Alzheimer’s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF) derivatives The BF framework aims to endow the conjugate mols. with ability for inhibition of AChE (bimodal way) and of amyloid-beta peptide aggregation, besides providing metal (Fe, Cu) chelating ability and concomitant extra anti-oxidant activity, for the hybrids with hydroxyl substitution. The new TAC-BF conjugates showed very good activity for AChE inhibition (sub-micromolar range) and good capacity for the inhibition of self- and Cu-mediated Aβ aggregation, with dependence on the linker size and substituent groups of each main moiety. Neuroprotective effects were also found for the compounds through viability assays of neuroblastoma cells, after Aβ1-42 induced toxicity. Structure-activity relationship anal. provides insights on the best structural parameters, to take in consideration for future studies in view of potential applications in AD therapy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to tacrine benzofuran hybrid preparation alzheimer’s antioxidant, ache inhibitors, alzheimer’s disease, metal chelators, multi-target drugs, tacrine-benzofuran hybrids, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Listunov, Dymytrii; Joly, Etienne; Duhayon, Carine; Saffon-Merceron, Nathalie; Fabing, Isabelle; Genisson, Yves; Maraval, Valerie; Chauvin, Remi published an article in 2018, the title of the article was Methinylogation Approach in Chiral Pharmacophore Design: from Alkynyl- to Allenyl-carbinol Warheads against Tumor Cells.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Extension of a structure-activity relationship study of the antitumor cytotoxicity of lipidic dialkynylcarbinols (DACs) is envisaged by formal methinylogation of one of the ethyndiyl moieties of the DAC warhead into the corresponding allenylalkynylcarbinol (AllAC) counterpart. External AllACs were directly obtained by methinylation of the parent DACs with formaldehyde in either the racemic or scalemic series. Isomers containing external propargyl and propynyl motifs were also prepared Internal AllACs were obtained as racemic statistical mixtures of stereoisomers in two steps from the key C5-DAC rac-TIPS-C C-CH(OH)-C CH and aldehydes. Kinetic resolution of the (S)-C5-DAC in 97 % ee and (R)-C5-DAC in 99 % ee was achieved by sequential lipase-mediated acetylation/hydrolysis using the Candida antartica lipase (Novozyme 435). The four internal AllAC stereoisomers were prepared by asym. methinylation with (R)- or (S)-diphenylprolinol as chiral auxiliary. Cytotoxicity assays on HCT116 cancer cells showed that the most active (eutomeric) external or internal AllAC exhibits an S configuration, a fatty chain length of n=12, and a 50 % inhibitory concentration IC50≈1.0 μM. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to methinylogation chiral pharmacophore alkynyl allenyl carbinol preparation antitumor, alkynes, allenes, antitumor agents, asymmetric synthesis, lipidic alkynylcarbinols, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 30, 2015, Esteve-Turrillas, Francesc A.; Mercader, Josep V.; Agullo, Consuelo; Abad-Somovilla, Antonio; Abad-Fuentes, Antonio published an article.Application of 35444-44-1 The title of the article was Moiety and linker site heterologies for highly sensitive immunoanalysis of cyprodinil in fermented alcoholic drinks. And the article contained the following:

Cyprodinil is a new-generation anilinopyrimidine fungicide widely used in crop protection and frequently found in fruits. In this study, novel derivatives of cyprodinil with linker site heterologies were synthesized and employed in order to produce antibodies with enhanced affinity. Moreover, moiety-heterologous haptens were designed and prepared for assay sensitivity improvement. Two competitive enzyme-linked immunosorbent assays for the anal. of this active substance were developed using direct and indirect formats, achieving IC50 values around 0.15 μg/L. Anal. figures of merit and usability of the optimized assays were evaluated with wine and cider as model food processed matrixes. The obtained recoveries were from 90% to 120%, and the limit of quantification was in the 1-5 μg/L range. Finally, a monitoring study (n = 150) was performed to estimate the occurrence and the concentration of cyprodinil in com. wine and cider products from different origins. We found that 28% of the analyzed wine samples contained cyprodinil residues at levels higher than 5 μg/L. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to cyprodinil hapten antibody wine cider elisa, Food and Feed Chemistry: Analysis and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics