Month: November 2022

Madaiah, M. published the artcileSynthesis and structure-activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is diazaspirodecanedione amino fluorophenoxyethyl preparation anticonvulsant.

A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives was synthesized and their pharmacol. activity was determined with the objective to better understand their structure-activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) test and their neurotoxic effects were determined by rotarod test. Majority of the compounds were active in MES tests. Compounds I [R = 4-MeC6H4NHCO, 3-MeC6H4NHCO, 2-CF3C6H4NHCO] showed a significant and protective effect on seizure, when compared with standard drug phenytoin. The compounds having an amide bond showed moderate protective effect on MES induced seizures compared to sulfonamide.

Medicinal Chemistry Research published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, Praveen published the artcileComputational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N′-[substituted]-acetohydrazides, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is anticonvulsant drug psychomotor seizure test; 2-(1; 3-benzodioxol-5-yloxy)-N’-[substituted]-acetohydrazides; 6 Hz psychomotor seizure test; computational study; docking; neurotoxicity.; synthesis.

About 50 million epileptic cases worldwide and 12 million in India are reported. Currently, available drugs yield adequate control of seizure in 60-70% of patients and show many toxic effects. These actualities provoked the search for novel, more efficacious and safer anticonvulsants. The concatenation of 2-(1,3-benzodioxol-5-yloxy)-N′-[substituted]-acetohydrazides SA 1- 10 was designed by mol. hybridization, optimized by computational study and synthesized with the objective of obtaining a prototype of potent anticonvulsant mols. especially active against partial seizures. Computational study was performed to calculate the pharmacophoric design, projection of the pharmacokinetic parameters and docking scores of the titled compounds with mol. targets of epilepsy. The anticonvulsant activity was ascertained by 6 Hz psychomotor seizure test. Minimal motor impairment showing neurotoxicity was assessed using the Rotarod test. Titled compounds possessed the indispensable elements of pharmacophore and displayed good binding affinity with mol. targets of epilepsy, such as GABA (A) alpha-1 & delta receptor, glutamate receptor, Na+/H+ exchanger and GABA- aminotransferase in docking studies. The most potent compound of the concatenation was 2-(1,3-benzodioxol-5-yloxy)-N′-[4-(4- chlorophenoxy)benzylidene]-acetohydrazide SA 4, showing 100% protection at four different time points with ED50 value 146.8 mg/kg at a TPE of 1 h in mice. The protection shown in 6 Hz test is implicated as the compound′s ability to control partial seizures. Thus, the titled compounds can be considered as potential prototype candidates for antiepileptic therapy against partial seizures.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, Laxmi published the artcileDesign, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is phenyl benzylidene hydrazinecarbothioamide preparation; epilepsy anticonvulsant neurotoxicity structure activity docking pharmacokinetic study.

Thirty six new N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothioamides were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity was established in three seizure models i.e. MES, scMET and 6 Hz model. The most active compound was 2-[4-(4-chlorophenoxy)benzylidene]-N-(4-fluorophenyl)hydrazinecarbothioamide, I, which showed 100% protection at 0.5 h in the 6 Hz test. Compound 2-[4-(4-bromophenoxy) benzylidene]-N-(4-bromophenyl) hydrazinecarbothioamide, II, was found to be active in both the MES and 6 Hz test. A computational study was carried out from calculation of a pharmacophore pattern and the prediction of pharmacokinetic properties. Titled compounds have also exhibited good binding properties with epilepsy mol. targets such as glutamate, GABA (A) delta and GABA (A) alpha-1 receptors, in the Lamarckian genetic algorithm based on flexible docking studies.

European Journal of Medicinal Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tripathi, Laxmi published the artcileAnticonvulsant and neurotoxicity evaluation of some novel cyclohexyl-[4-substituted benzylidene/2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazides, Application In Synthesis of 61343-99-5, the main research area is cyclohexyl amine reaction carbon sulfide hydrazine; thiosemicarbazide cyclohexyl preparation condensation aryl aldehyde; isatin condensation cyclohexyl thiosemicarbazide; arylidene thiosemicarbazide preparation anticonvulsant neurotoxicity activity; indolonylidene thiosemicarbazide preparation anticonvulsant neurotoxicity activity; thiosemicarbazone preparation anticonvulsant neurotoxicity activity.

A series of novel cyclohexyl-[4-substituted benzylidene/2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazides were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and s.c. metrazol (scMET) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. The compounds cyclohexyl-[4-(4-chlorophenoxy)-benzylidene]thiosemicarbazide and cyclohexyl-[2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazide emerged as the most promising one with anti-MES activity in mice i.p. All the compounds exhibited no neurotoxicity in rotorod method.

Asian Journal of Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application In Synthesis of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Madaiah, Malavalli published the artcileSynthesis and Pharmacological Evaluation of Novel 1′-[2-(Difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-diones and Their Derivatives, Related Products of chlorides-buliding-blocks, the main research area is difluoromethoxyphenylmethyl spiro azabicyclooctane imidazolidine preparation anticonvulsant; Anticonvulsant; Isocyanate; Maximal electroshock; ScPTZ; Spirohydantoins.

A series of novel 1′-[2-(difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione substituted hydantoins was synthesized using an appropriate synthetic route and characterized by elemental anal. and spectral data. The novel mols. were screened for anticonvulsant activity in mice by maximal electroshock (MES) and s.c. pentylenetetrazol (ScPTZ)-induced seizure tests. The neurotoxicity was assessed using the rotarod method. Several compounds exhibited anticonvulsant activity in an MES seizure model and in a ScPTZ model, with lower neurotoxicity. Some title compounds showed lower central nervous system depression compared to phenytoin. The synthesis of the target compounds was achieved by a reaction of [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione with arenesulfonyl chlorides or aryl isocyanates. The title compounds thus formed included [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione sulfonamide analogs , such as a 4-fluoro-2-methylbenzenesulfonamide analog (I) and [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione amide analogs.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nageswara Rao, Ramisetti published the artcileRP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: Method development and validation, Name: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, the main research area is carisbamate impurity degradation product separation HPLC mass spectrometry.

A stability indicating reversed phase HPLC method was developed and validated for determination of process related impurities and forced degradants of carisbamate (CRS) in bulk drugs. Carisbamate when subjected to acid/base hydrolysis, H2O2 oxidation, photolysis and thermal stress significant degradation was observed during acid/base hydrolysis and the degradants were isolated and characterized by ESI-MS, 1H and 13C NMR. MS/MS and 2D-NMR (COSY and HSQC) studies revealed the possible isomerization of CRS under stress conditions. The optimum separation was accomplished on Agilent XDB C18 column (150 mm × 4.6 mm; 5 μm) using 0.02 M KH2PO4 (pH = 3.5) and CH3CN as a mobile phase in a gradient elution mode at a flow rate of 1.0 mL/min. The eluents were monitored by PDA detector at 211 nm and quantitation limits were obtained in the range of 0.1-0.3 μg/mL for CRS, degradants and other impurities. The LC method was validated with respect to accuracy, precision, linearity, robustness and limits of detection and quantification as per ICH guidelines.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Acid hydrolysis. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Name: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ohi, Nobuhiro published the artcileSemisynthetic β-lactam antibiotics. III. Effect on antibacterial activity and COMT susceptibility of chlorine introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido]penicillanic acid, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is penicillanic acid antibacterial; catechol methyl transferase metabolism penicillinate.

The resistance of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido]penicillanic acid (I) [81819-61-6] to metabolism by catechol-O-methyl-transferase  [9012-25-3] was increased by introduction of the Cl atom into the catechol moiety. Penicillins having 1 or 2 Cl atoms at the positions adjacent to the OH had greater stability to COMT. This resulted in greater efficiency in vivo in exptl. Pseudomonas aeruginosa and Escherichia coli infections. In vitro activities were essentially unchanged.

Journal of Antibiotics published new progress about Escherichia coli. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamamura, Ei-Tora published the artcileA novel method of producing the pharmaceutical intermediate (R)-2-chloromandelic acid by bioconversion, Safety of (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, the main research area is chloromandelic Exophiala dermatitidis hydrolysis bioconversion; 2-chloromandelic acid; Asymmetric hydrolysis; bioconversion; esterase; expression.

(R)-2-Chloromandelic acid (RCM) is one of the chiral building blocks used in the pharmaceutical industry. As a result of screening for microorganisms that asym. hydrolyze racemic 2chloromandelic acid Me ester (CMM), Exophiala dermatitidis NBRC6857 was found to produce RCM at optical purity of 97% ee. The esterase that produces RCM, EstE, was purified from E. dermatitidis NBRC6857, and the optimal temperature and pH of EstE were 30°C and 7.0, resp. The estE gene that encodes EstE was isolated and overexpressed in Escherichia coli JM109. The activity of recombinant E. coli JM109 cells overexpressing estE was 553 times higher than that of E. dermatitidis NBRC6857. RCM was produced at conversion rate of 49% and at optical purity of 97% ee from 10% CMM with 0.45 mg-dry-cell/L recombinant E. coli JM109 cells. Based on these findings, RCM production by bioconversion of CMM may be of interest for future industrial applications.

Bioscience, Biotechnology, and Biochemistry published new progress about Escherichia coli. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Safety of (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Puleo, Thomas R. published the artcileCatalytic α-Selective Deuteration of Styrene Derivatives, Quality Control of 93118-03-7, the main research area is deuterostyrene regioselective chemoselective preparation; regioselective monodeuteration electron deficient styrene base catalyzed addition alc; dependence styrene deuteration chemoselectivity alc concentration.

Styrenes such as 4-trifluoromethylstyrene (particularly electron-deficient styrenes) underwent chemoselective and regioselective α-deuteration with DMSO-d6 in the presence of alcs. (either methanol or 1-cyclopropylethanol) and KO-t-Bu via base-catalyzed reversible addition of alkoxides to styrenes. The concentration of methanol is critical for high yields and selectivities to maximize the yield of deuteration over formation of polystyrenes; 1-cyclopropylethanol minimized the formation of nucleophilic substitution product in the monodeuteration of 2-chloro-3-vinylpyridine. The deuterated styrenes were used in the preparation of compounds with deuterated benzylic stereocenters.

Journal of the American Chemical Society published new progress about Chemoselectivity. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nencini, Arianna published the artcileDesign and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor, Category: chlorides-buliding-blocks, the main research area is SAR preparation alpha 7 nicotinic acetylcholine receptor agonist preparation; drug design mol docking chem library preparation; Alzheimer’s disease; Cognition; Neuronal nicotinic acetylcholine receptors; Nicotinic ligands; Schizophrenia.

α7 Nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chem. program we investigated a novel series of α7 nAChR agonists. Starting from mol. docking studies on two series of mols. recently developed in our laboratories, an alternative scaffold was designed attempting to combine the optimal features of these previously identified urea and pyrazole compounds Based on our previous SAR knowledge and on predicted drug-like properties, a small library was synthesized in parallel manner, affording compounds with excellent α7 nAChR activity, selectivity and preliminary ADME profile.

European Journal of Medicinal Chemistry published new progress about Chemical library. 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics