Month: November 2022

Abd El-Bary, H.’s team published research in Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems in 47 | CAS: 10543-42-7

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Abd El-Bary, H. published the artcileReactions with coumarin. II, COA of Formula: C9H5ClO4S, the publication is Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems (1995), 47(1), 43-8, database is CAplus.

Coumarin-6-sulfonyl chloride reacted with o-, m-, p-phenylenediamine to give the sulfonamides I (R = 2-, 3-, 4-H2NC6H4). Phenylisocyanate or phenylisothiocyanate reacted with I yielding the urea derivatives Condensation of I with acetaldehyde or acetophenone gave the imines. The sulfonic acid esters were formed through condensation of coumarin-6-sulfonyl chloride with phenolic derivatives

Modelling, Measurement & Control, C: Energetics, Chemistry, Earth, Environmental & Biomedical Problems published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kamlet, Mortimer J.’s team published research in Journal of Organic Chemistry in 48 | CAS: 866-23-9

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Kamlet, Mortimer J. published the artcileLinear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, π*, α, and β, and some methods for simplifying the generalized solvatochromic equation, SDS of cas: 866-23-9, the publication is Journal of Organic Chemistry (1983), 48(17), 2877-87, database is CAplus.

A generalized equation for linear solvation energy relations or complexation energy relations is developed which involves 6 terms: π* (a solvent dipolarity-polarizability term), α (solvent hydrogen-bond acceptor term), β (solvent hydrogen-bond donor term), δ (solvent polarizability correction term), δH (Hildebrand solubility parameter), and ξ. This equation is reduced to a more manageable form by a judicious choice of solvents and reactants or indicators. One-, two- or three-parameter LFER involving different combinations of the above parameters and various types of physicochem. properties are observed A comprehensive collection of π*, α, and β for 217 solvents is presented.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Elwaie, Tamer A.’s team published research in Journal of Medicinal Chemistry in 63 | CAS: 350-30-1

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Elwaie, Tamer A. published the artcileHER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2020), 63(24), 15906-15945, database is CAplus and MEDLINE.

HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with aggressive clin. outcomes; thus, herein we present structural optimization for HER2-selective targeting. HER2 profiling of the developed derivatives demonstrated potent and selective inhibitions (IC50: 5.4-12 nM) compared to lapatinib (IC50: 95.5 nM). Favorably, 17d exhibited min. off-target kinase activation. NCI-5-dose screening revealed broad-spectrum activities (GI50: 1.43-2.09μM) and 17d had a remarkable selectivity toward BC. Our compounds revealed significant selective and potent antiproliferative activities (~20-fold) against HER2+ (AU565, BT474) compared to HER2(-) cells. At 0.1 IC50, 15i, 17d, and 25b inhibited pERK1/2 and pAkt by immunoblotting. Furthermore, 17d demonstrated potent in vivo tumor regression against the BT474 xenograft model. Notably, a metastasis case was observed in the vehicle but not in the test mice groups. CD-1 mice metabolic stability assay revealed high stability and low intrinsic clearance of 17d (T1/2 > 145 min and CLint(mic) < 9.6 mL/min/kg).

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lumma, William C. Jr.’s team published research in Journal of Medicinal Chemistry in 1981-01-31 | CAS: 55687-19-9

Journal of Medicinal Chemistry published new progress about serotoninmimetic piperazinylquinoxaline; serotoninin reuptake blocking quinoxaline; piperazinylquinoxaline; quinoxaline piperazinyl. 55687-19-9 belongs to class chlorides-buliding-blocks, name is 5-Chloroquinoxalin-2-ol, and the molecular formula is C8H5ClN2O, Safety of 5-Chloroquinoxalin-2-ol.

Lumma, William C. Jr. published the artcilePiperazinylquinoxalines with central serotoninmimetic activity, Safety of 5-Chloroquinoxalin-2-ol, the main research area is serotoninmimetic piperazinylquinoxaline; serotoninin reuptake blocking quinoxaline; piperazinylquinoxaline; quinoxaline piperazinyl.

The piperazinylquinoxalines I (R = H, Ac, Me; R1 = H, OH (and the related ketone), CO2H; R2, R3 = H, Cl, NH2, CF3, SPh, OMe, F, etc.; m, n = 0, 1) were prepared by various methods. I were tested for selectivity in regards to serotonin reuptake blocking and serotoninmimetic activity. In general, introduction of a 6-substituent into I enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted I and I (R1 = OH) had primary serotoninmimetic activity.

Journal of Medicinal Chemistry published new progress about serotoninmimetic piperazinylquinoxaline; serotoninin reuptake blocking quinoxaline; piperazinylquinoxaline; quinoxaline piperazinyl. 55687-19-9 belongs to class chlorides-buliding-blocks, name is 5-Chloroquinoxalin-2-ol, and the molecular formula is C8H5ClN2O, Safety of 5-Chloroquinoxalin-2-ol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Umio, Suminori’s team published research in Chemical & Pharmaceutical Bulletin in 1969 | CAS: 23082-45-3

Chemical & Pharmaceutical Bulletin published new progress about pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl. 23082-45-3 belongs to class chlorides-buliding-blocks, name is 3,5-Dichloro-2-nitrobenzoic acid, and the molecular formula is C7H3Cl2NO4, Quality Control of 23082-45-3.

Umio, Suminori published the artcileTotal synthesis of pyrrolnitrin. VI. Synthesis of nitrochloro-2-aminoacetophenones and 1-aryl-1,3-butanediones, Quality Control of 23082-45-3, the main research area is pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl.

Synthetic methods nitro-chloro-2-aminoacetophenones XYC6H3COCH(NH2)R (I) (X = 2-NO2, 3-NO2, 4-NO2; Y = 3-Cl, H, 4-Cl; and R = H, Me), and 1-(nitrochlorophenyl)-1,3-butanediones XYC6H3COCH2COCH2R (II) (X = 2-NO2, 4-NO2; Y = 3-Cl, H, 4-Cl, 5-Cl), starting materials for the synthesis of pyrrolnitrin (III) and related compounds, were investigated. Never rearrangement was suitable for the preparation of I. Cleavage of Et 2-(nitro-chlorobenzoyl) acetoacetate and a 2,4-pentanedione derivative led to II.

Chemical & Pharmaceutical Bulletin published new progress about pyrrolnitrin synthesis; acetophenones nitro chloro amino; butanediones aryl. 23082-45-3 belongs to class chlorides-buliding-blocks, name is 3,5-Dichloro-2-nitrobenzoic acid, and the molecular formula is C7H3Cl2NO4, Quality Control of 23082-45-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kas’yan, A. O.’s team published research in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2002-04-30 | CAS: 7079-48-3

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Formula: C7H6ClFO2S.

Kas’yan, A. O. published the artcileNew N-(arylsulfonyl)-5-aminomethylbicyclo[2.2.1]hept-2-enes. Synthesis, 1H and 13C NMR spectra, and chemical reactions, Formula: C7H6ClFO2S, the main research area is arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation.

N-(Arylsulfonyl)-5-aminomethylbicyclo[2.2.1]hept-2-enes (I) were obtained by reaction of stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-enes with arylsulfonyl chlorides. The contribution of the stereochem. features of the sulfonamides to the spectral structure of the endo- and exo-isomers of I was evaluated with the use of 1H and 13C NMR spectral data, including those of two-dimensional COSY and NOESY spectra. Phase-transfer catalysis alkylation and acylation of I was carried out. The reactions of endo- and exo-5-[N-benzyl-N-(3,4-dichlorophenylsulfonyl)aminomethyl]bicyclo[2.2.1]hept-2-enes with peroxyphthalic acid yielded epoxides; the orientation of substituents in the cage norbornene fragment does not affect the direction of this process.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Formula: C7H6ClFO2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yeager, Gary W.’s team published research in Synthesis in 1991-01-31 | CAS: 61343-99-5

Synthesis published new progress about arylphenol; phenol aryl. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Synthetic Route of 61343-99-5.

Yeager, Gary W. published the artcileA convenient method for the preparation of 4-aryloxyphenols, Synthetic Route of 61343-99-5, the main research area is arylphenol; phenol aryl.

The treatment of p-RC6H4OH (R = H, Cl, Br, CMe3, OMe, OPh, CO2Et) with p-FC6H4COR1 (I; R1 = H, Me) in the presence of K2CO3 gave di-Ph ethers II. The Baeyer-Villiger oxidation of II followed by acid hydrolysis gave 4-aryloxyphenols III. Bisphenols IV (X = p-C6H4, 4,4′-C6H4OC6H4, 4,4′-biphenylene) were prepared similarly from HOXOH and I.

Synthesis published new progress about arylphenol; phenol aryl. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Synthetic Route of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arcoleo, A.’s team published research in Journal of Heterocyclic Chemistry in 1986-08-31 | CAS: 35112-27-7

Journal of Heterocyclic Chemistry published new progress about acetyltetralone condensation benzoate; naphthopyranone phenyl. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Name: Ethyl 2,5-dichlorobenzoate.

Arcoleo, A. published the artcileReaction of 2-acetyltetralone with some esters of benzoic acid, Name: Ethyl 2,5-dichlorobenzoate, the main research area is acetyltetralone condensation benzoate; naphthopyranone phenyl.

Reaction of 2-acetylteralone (I) with RC6H4CO2Me (II, R = H, 4-Cl, 4-Me3C, 2-MeO, 2-EtO, 2-PrO) gave the corresponding triketones III, however reaction of I with II (R = 2-Cl) and 2,5-Cl2C6H3CO2Me gave III [R = 2-Cl, 2-MeO) and III (R = 2,5-Cl2, 2,5-(MeO)Cl] resp. Treating III with H2SO4 gave naphthopyranones IV.

Journal of Heterocyclic Chemistry published new progress about acetyltetralone condensation benzoate; naphthopyranone phenyl. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Name: Ethyl 2,5-dichlorobenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Dongpo’s team published research in Tetrahedron in 2013-08-19 | CAS: 61343-99-5

Tetrahedron published new progress about Air. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Quality Control of 61343-99-5.

Peng, Dongpo published the artcileA 2,2′-bipyridine-palladacycle catalyzed the coupling of arylboronic acids with nitroarenes, Quality Control of 61343-99-5, the main research area is diaryl ether preparation arylboronic acid nitroarene cross coupling; cross coupling arylboronic acid nitroarene bipyridine palladacycle catalyst.

A novel palladium-catalyzed protocol for the synthesis of diaryl ethers derivatives has been developed. In the presence of 2,2′-bipyridine-cyclopalladated ferrocenylimine complex, diaryl ethers were selectively generated by adjusting reaction parameters through the coupling of arylboronic acids and nitroarenes with yields ranging from poor to good. The efficiency of this reaction was demonstrated by its compatibility with a range of groups. Moreover, the rigorous exclusion of air or moisture was not required in these transformations.

Tetrahedron published new progress about Air. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Quality Control of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fujimura, Kazumi’s team published research in Journal of Liquid Chromatography in 1986-03-31 | CAS: 32345-60-1

Journal of Liquid Chromatography published new progress about HPLC. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Synthetic Route of 32345-60-1.

Fujimura, Kazumi published the artcileOptical resolution of some mandelic derivatives on a chemically bonded cyclodextrin stationary phase, Synthetic Route of 32345-60-1, the main research area is alkyl mandelate resolution liquid chromatog; cyclodextrin carbamate stationary phase chromatog; hydrogen bond cyclodextrin liquid chromatog; substituent effect resolution liquid chromatog; HPLC optical isomer carboxylic ester.

The preparation and use of a new type of cyclodextrin-carbamate-bonded stationary phase are described. HPLC resolution of racemic mandelates and their analogswas achieved by using this phase. The chiral recognition was explained in terms of a 3-point attachment model. In addition to the inclusion of the aromatic ring of the sample into the cavity of cyclodextrin, enantioselective interaction occurs at 2 other points; H bonding of the 2 polar substituents on the asym. C atom with secondary hydroxyl groups on the rim of the wider opening face of the cyclodextrin mol. The effect of the type and position of substituents and other factors responsible for the resolution is discussed.

Journal of Liquid Chromatography published new progress about HPLC. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Synthetic Route of 32345-60-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics