Month: November 2022

B(C₆F₅)₃-catalyzed synthesis of coumarins via Pechmann condensation under solvent-free conditions was written by Prajapti, Santosh Kumar;Rao, S. Prakash. And the article was included in Monatshefte fuer Chemie in 2021.Formula: C6H9ClO3 The following contents are mentioned in the article:

Tris(pentafluorophenyl)borane [B(C₆F₅)₃] catalyzed simple, efficient and environmentally benign protocol has been developed for the Pechmann condensation using variety of phenols and β-ketoesters under solvent-free conditions to afford coumarin derivatives The present protocol displayed significant advantages such as low catalyst loading, short reaction time, mild reaction conditions, low toxicity, easy work-up, high yields, and compatibility with other functional groups. In addition, it is a convenient, clean, and fast alternative approach for synthesizing variety of coumarin derivatives Moreover, the applicability of this method towards large-scale synthesis demonstrated its suitability for the industrial application. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Studies on the biological activity of heterocyclic compounds. Part IV. On the blinding activities and acute oral toxicities of aminobenzenes, pyrimidines, purines, amino-s-triazines and their related compounds in baby chicks was written by Obara, Yoshihiko;Umemoto, Yasunaga;Matsubara, Hiromichi. And the article was included in Nippon Nogei Kagaku Kaishi in 1981.Related Products of 2272-40-4 The following contents are mentioned in the article:

Feeding experiments were carried out on male chicks with 44 title compounds When formoguanamine (I) [504-08-5] and 2-amino-s-triazine (II) [4122-04-7] were given to chicks orally (1% active ingredient), blindness resulted. Introduction of the N-substituted amino group(s) into these 2 compounds did not cause blindness. Phenylenediamines (1% active ingredient) had acute toxicities and aminodichloro-s-triazines (1% active ingredient) the strongest lethal toxicities. 2,4-Bis(diethylamino)- [1898-73-3] and 2-ethylamino-4-isopropylamino-s-triazine  [4150-65-6] (3% active ingredient) caused loss of appetite in baby chicks. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis 1-[4-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-2-propen-1-one and 1-[3-[4-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-1H-pyrazol-1-yl]ethanone and 2-amino-6-[4-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-3-pyridinecarbonitrile derivatives and determination of their activity as antibacterial agents was written by Kapadia, Kishor;Solankee, Pankit;Prajapati, Yogesh;Patel, Hiral;Solankee, Sejal;Solankee, Anjani. And the article was included in Organic Chemistry: An Indian Journal in 2007.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A method for the synthesis of the title compounds is reported here. The target compounds thus prepared included 1-[4-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-2-propen-1-one derivatives and 1-[3-[4-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-1H-pyrazol-1-yl]ethanone derivatives and 2-amino-6-[4-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]phenyl]-3-pyridinecarbonitrile derivatives All the synthesized compounds have been screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella paratyphi-B (Salmonella schottmuelleri). The constitutions of newly synthesized compounds have been established on the basis of their elemental anal., IR and ¹H NMR spectral data. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New Simple and Robust Method for Determination of Polarity of Deep Eutectic Solvents (DESs) by Means of Contact Angle Measurement was written by Cichocki, Lukasz;Warminska, Dorota;Luczak, Justyna;Przyjazny, Andrzej;Boczkaj, Grzegorz. And the article was included in Molecules in 2022.Computed Properties of C25H46ClN The following contents are mentioned in the article:

The paper presents a new method for evaluating the polarity and hydrophobicity of deep eutectic solvents (DESs) based on the measurement of the DES contact angle on glass. DESs consisting of benzoic acid derivatives and quaternary ammonium chlorides-tetrabutylammonium chloride (TBAC) and benzyldimethylhexadecylammonium chloride (16-BAC)-in selected molar ratios were chosen for the study. To investigate the DESs polarity, an optical goniometer and an ET(30) solvatochromic scale based on Reichardt’s dye were used. The research demonstrated the high accuracy and precision of the developed procedure. The simplicity of the examination and the availability of basic equipment allow for the implementation of the developed method in routine investigations of DESs. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Computed Properties of C25H46ClN).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C25H46ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective Construction of Diverse Polycyclic Spirooxindoles via a Three-Component Reaction of Cyclic Mercapto-Substituted β-Enamino Esters, Isatins, and Cyclic 1,3-Diketones was written by Sun, Quan-Shun;Sun, Jing;Pan, Liu-Na;Yan, Chao-Guo. And the article was included in Journal of Organic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The three-component reaction of alkyl 2-(benzo[b][1,4]thiazin-3-ylidene)acetates, isatins, and 1,3-indanedione (1,3-cyclopentanedione) in ethanol in the presence of acetic acid conveniently afforded spiro[indeno[1,2-b]phenothiazine-6,3′-indolines] or spiro[cyclopenta[b]phenothiazine-4,3′-indolines] in good yields and with high diastereoselectivity. More interestingly, a similar three-component reaction with 4-hydroxychromen-2-one resulted in the unexpected polycyclic spiro[benzo[b]chromeno[3′,4′:5,6]pyrano[2,3-e][1,4]thiazine-7,3′-indolines] in satisfactory yields. A plausible reaction mechanism was rationally proposed for formation of different kinds of the spiro compounds, and the stereochemistries of the various spiro compounds were clearly elucidated. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Halogen-rich halorhenates(IV): (Me₄N)₂{[ReX₆](X₂)} (X = Cl, Br) was written by Korobeynikov, Nikita A.;Usoltsev, Andrey N.;Sukhikh, Taisiya S.;Novikov, Alexander S.;Korolkov, Ilya V.;Fedin, Vladimir P.;Sokolov, Maxim N.;Adonin, Sergey A.. And the article was included in Polyhedron in 2022.SDS of cas: 75-57-0 The following contents are mentioned in the article:

Dihalogen – halorhenates(IV) (Me₄N)₂{[ReX₆](X₂)} (X = Cl 1, Br 2) were prepared and structurally characterized, featuring the 1st examples of Re/dihalogen supramol. complexes. 1 And 2 reveal pseudo-3D structure; both compounds demonstrate high thermal stability, releasing Cl₂ or Br₂ only at elevated temperatures (over 90 and 150°, resp.). The energies of halogen···halogen noncovalent interactions are â‰?.5 and 5.1 kcal/mol for 1 and 2, resp. Hirshfeld surface anal. was performed for both structures, allowing estimation of contributions of different noncovalent interactions to crystal packing. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0SDS of cas: 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adsorption of silicate anions from geothermal brine using chitosan-polyethylene glycol composite to prevent silica scaling on the Dieng Geo Dipa geothermal energy system was written by Hayati, Nur;Humaida, Hanik;Siswanta, Dwi. And the article was included in Indonesian Journal of Chemistry in 2021.Quality Control of N-Methyl-N,N-dioctyloctan-1-aminium chloride The following contents are mentioned in the article:

Silica scaling is a common problem in geothermal power generation facilities which inhibits electricity generation. In order to provide a solution to this problem, the removal of silicate ions using CPEG-TOMAC (Chitosan-polyethylene glycol-trioctyl Me ammonium chloride) membrane adsorbent was investigated for geothermal brine from Geo Dipa Energy, Dieng. The process is dependent on contact time, pH, and the concentration of silicate. An adsorption batch study that used adsorbents for the geothermal brine of the Dieng Geo Dipa reactor 28A showed that CPEG TOMAC at pH 6 resulted in an adsorption capacity of 72.6 mg g^-1. Furthermore, the adsorption of silicate ions onto the membrane followed pseudo-second-order kinetics and the Freundlich isotherm model. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Quality Control of N-Methyl-N,N-dioctyloctan-1-aminium chloride).

N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of N-Methyl-N,N-dioctyloctan-1-aminium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manganese-Catalyzed Borylation of Unactivated Alkyl Chlorides was written by Atack, Thomas C.;Cook, Silas P.. And the article was included in Journal of the American Chemical Society in 2016.COA of Formula: C6H12BrCl The following contents are mentioned in the article:

The use of low-cost manganese(II) bromide (MnBr₂) and tetramethylethylenediamine (TMEDA) catalyzes the cross coupling of (bis)pinacolatodiboron with a wide range of alkyl halides, demonstrating the first manganese-catalyzed coupling with alkyl electrophiles. This method allows access to primary, secondary, and tertiary boronic esters from the parent chlorides, which were previously inaccessible as coupling partners. The reaction proceeds in high yield with as little as 1000 ppm catalyst loading, while 5 mol % can provide high yields in as little as 30 min. Finally, radical-clock experiments revealed that at 0 °C direct borylation outcompetes alternative radical processes, thereby providing synthetically useful, temperature-controlled reaction outcomes. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3COA of Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and characterization of some new non-symmetric substituted triazines and triazine derivatives was written by Thakare, S. S.;Dhote, S. N.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2020.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Attempts were made to carry out the laboratory synthesis of non-sym. mono-, di- and tri- substituted 1,3,5-triazines I (R = Et, Ph, 2,5-dimethylphenyl, 4-nitrophenyl, etc.; R¹ = Cl, naphthalen-1-oxy; R² = Cl, benzothiazol-2-ylsulfanyl, phenylsulfanyl) by the action of the electron-donating substituent on 2,4,6-trichloro-1,3,5-triazine by aromatic nucleophilic substitution reaction mechanism (SNAr reaction) by temperature controlled. The introduction of the amino group (-NH-), ether (-O-) and thiol (-S-) Linker Bridge show more promising antibacterial activity. The yield of newly synthesized compounds I was quite well, and their structures were confirmed by using IR, ¹H NMR, and Mass spectral data. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The Highly Regioselective Synthesis of Novel Imidazolidin-2-ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity was written by Gazizov, Almir S.;Smolobochkin, Andrey V.;Kuznetsova, Elizaveta A.;Abdullaeva, Dinara S.;Burilov, Alexander R.;Pudovik, Michail A.;Voloshina, Alexandra D.;Syakaev, Victor V.;Lyubina, Anna P.;Amerhanova, Syumbelya K.;Voronina, Julia K.. And the article was included in Molecules in 2021.Reference of 95-88-5 The following contents are mentioned in the article:

A series of novel 4-(het)arylimidazolidin-2-ones I [R = 5-Cl-2,4-di-HO-C₆H₂, 6-hydroxy-1,3-benzodioxol-5-yl, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl; R¹ = H, Me; R² = Ph, 4-MeC₆H₄, 3-ClC₆H₄, etc.] was obtained by the acid-catalyzed reaction of (2,2-dimethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones I benefited from excellent regioselectivity, readily available starting materials and a simple procedure. The regioselectivity of the reaction was rationalized by quantum chem. calculations and control experiments The anti-cancer activity of the obtained compounds was tested in vitro. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Reference of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics