DBU/AgOTf Relay-Catalysis Enabled One-Pot Synthesis of 1,3-Dihydroisobenzofurans and Its Conversion to Indanones was written by Wang, Jiazhuang;Huang, Hongtai;Gao, Haotian;Qin, Guiping;Xiao, Tiebo;Jiang, Yubo. And the article was included in Advanced Synthesis & Catalysis in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
A DBU/AgOTf relay-catalyzed one-pot reaction of 2-alkynylbenzaldehydes and α-diazo esters for the efficient construction of 1,3-dihydroisobenzofuran derivatives was documented. This protocol can tolerate a wide range of substrates and its scalability was demonstrated by the gram-scale reaction. Moreover, the obtained 1,3-dihydroisobenzofurans were converted to indanone derivatives by a AgOTf-catalyzed ring recombination process. Both of the resulting products, 1,3-dihydroisobenzofurans and indanones, are important structural units of a variety of pharmaceuticals and natural products, and their structures are clearly confirmed by single crystal X-ray diffraction anal. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Category: chlorides-buliding-blocks).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics