Semi-Industrial Fluorination of β-Keto Esters with SF4 : Safety vs Efficacy was written by Trofymchuk, Serhii A.;Kliukovskyi, Denys V.;Semenov, Sergey V.;Khairulin, Andrii R.;Shevchenko, Valerii O.;Bugera, Maksym Y.;Tarasenko, Karen V.;Volochnyuk, Dmitriy M.;Ryabukhin, Sergey V.. And the article was included in Synlett in 2020.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
The possibility of deoxofluorination of β-keto esters using SF4 was investigated. The scope and limitation of the reaction were determined The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chem., were synthesized on multigram scale. The safety of SF4 use was discussed. The described method does not improve upon the safety of using SF4, but practical recommendations for working with the reagent were proposed. Despite the hazards of using toxic SF4, a significant increase of efficacy in the synthesis of medicinal-chem.-relevant building blocks, based on the reaction, in comparison with earlier described approaches was shown. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics