Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents was written by Solankee, Anjani;Kapadia, Kishor;Ciric, Ana;Sokovic, Marina;Doytchinova, Irini;Geronikaki, Athina. And the article was included in European Journal of Medicinal Chemistry in 2010.Synthetic Route of C9H6Cl2N4 The following contents are mentioned in the article:
Base-catalyzed condensation of a ketone with different aldehydes gave chalcones, 2.4-bis-(phenylamino)-6-[4′-{3”-(4”’-substituted phenyl/2”’-furanyl/2”’-thienyl)-2”-propenon-1”-yl}phenylamino]-s-thriazines. The chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines, aminopyrimidines, e.g., I (R = Cl, NO2), and cyanopyridines, resp. All the four series of products were fully characterized by spectroscopic and elemental anal., and also tested for their antibacterial activity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Synthetic Route of C9H6Cl2N4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C9H6Cl2N4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics