Synthesis of Functionalised Chromonyl-pyrimidines and Their Potential as Antimycobacterial Agents was written by Santoso, Kristiana T.;Brett, Matthew W.;Cheung, Chen-Yi;Cook, Gregory M.;Stocker, Bridget L.;Timmer, Mattie S. M.. And the article was included in ChemistrySelect in 2020.SDS of cas: 638-07-3 The following contents are mentioned in the article:
Herein, the development of chromonyl-pyrimidines I [R1 = Me, CH2Cl, CH2OMe, Ph, 4-FC6H4; R2 = H, C(O)Ph; R3 = CO2H, CO2Et, Ph, 4-NH2C6H4, 4-O2NC6H4] as a new tuberculosis (TB) drug scaffold was presented. A library of chromonyl-pyrimidines was synthesized, from which lead compounds I [R1 = Me, R2 = H, Ph R3 = Ph; R1 = Me, R2 = R3 = Ph] was identified. From this work, the potential of chromonyl-pyrimidines as therapeutics for TB was demonstrated. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics