In vitro antimicrobial assessment of coumarin-based s-triazinyl piperazines was written by Patel, Divyesh;Patel, Rahul;Kumari, Premlata;Patel, Navin. And the article was included in Medicinal Chemistry Research in 2012.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:
A series of 1,3,5-triazines containing aniline, coumarins (4-hydroxycoumarin and 7-hydroxy-4-methylcoumarin), and different piperazine moieties as substituent on the C atoms of the triazine ring were synthesized by a simple and efficient synthetic protocol. Comparative studies were performed on the above series, which was prepared via amination of appropriate chlorotriazines with conventional and microwave heating. The microwave method was observed to be more beneficial as it provides an increase in yield and 90-95% reduction of time. All the synthesized compounds were examined for their efficacy against Gram -ve bacteria (E. coli and P. aeruginosa), Gram +ve bacteria (S. aureus and B. subtilis), and fungal species (C. albicans and A. niger) with an intent to overcome multiple drug resistance to the pathogenic strains. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics