Synthesis of 4-(1H-isochromen-1-yl)isoquinolines through the silver-catalyzed homodimerization of ortho-alkynylarylaldehydes and subsequent condensation of the 1,5-dicarbonyl motif with NH3 was written by Guo, Minghui;Meng, Xin;Zhao, Yang;Dong, Yuexia;Sun, Xuejun;Tian, Laijin;Cao, Ziping. And the article was included in RSC Advances in 2019.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
4-(1H-Isochromen-1-yl)isoquinoline derivatives I (R1 = H, 7-OMe, 7-Cl, 6-Me, etc.; R2 = C6H5, 4-MeC6H4, 3-FC6H4, 4-NCC6H4, etc.) were synthesized in high yields via the AgBF4-catalyzed self-reaction of ortho-alkynylarylaldehydes to give isochromene intermediates, followed by the dehydration of the 1,5-dicarbonyl motif with NH3. Compared with electron-rich aromatic substituents, this strategy can provide the desired isochromene products with an electron-deficient isoquinoline unit. The reactions feature simple exptl. operations, mild reaction conditions and high product yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics