A Visible Light Ru-Catalyzed Photoredox Access to Substituted Dihydrofurans was written by Victoria-Miguel, Jorge;Garcia-Santos, William H.;Cordero-Vargas, Alejandro. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
An efficient, visible light Ru(bpy)3Cl2-catalyzed method for the preparation of 2,3-dihydrofurans I [R1 = CH2Cl, Ph, 2-thienyl, etc.; R2 = Me, Et, TBS; R3 = H, Me, Ph] and II [X = a bond, CH2] was reported. This approach employed 2-bromoketoesters as radical precursors and alkyl enol ethers as acceptors. The photoredox cycle furnished an oxonium ion that was captured by an internal nucleophile to render the corresponding dihydrofurans. Moreover, the obtained products contained a versatile acetal moiety at C-2, allowing its transformation into a diverse variety of heteroaromatic and nonaromatic compounds This method could served as an important tool in the synthesis of complex tetrahydro- and dihydrofurans as well as heteroaromatic structures. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics