Synthesis of substituted isoquinolines via iminoalkyne cyclization using Ag(I) exchanged K10-montmorillonite clay as a reusable catalyst was written by Jeganathan, Mariappan;Pitchumani, Kasi. And the article was included in RSC Advances in 2014.HPLC of Formula: 1186603-47-3 The following contents are mentioned in the article:
Monosubstituted isoquinolines were synthesized in good to excellent yields by the Ag(I)-exchanged K10-montmorillonite clay catalyzed ring closure of iminoalkynes. This silver catalyzed ring closure was highly effective in cyclizing aryl- and alkyl-substituted iminoalkynes at 100 ° and accommodated a variety of iminoalkynes, thus affording a convenient route to the synthesis of isoquinolines. The other salient features of this procedure were its reusability, environmentally benign nature, high yield, operational simplicity with fewer steps, easy separation and minimization of metallic wastes. The reaction proceeded smoothly in moderate yields and tolerated various functional groups. The solid catalyst was readily recovered and reused. Notably, no addnl. base or other co-catalysts were needed. A plausible mechanism was proposed in which isoquinolines were formed via simultaneous bifunctional acid-base catalysis by Ag(I) clay. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3HPLC of Formula: 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics