Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium was written by Ueoka, Reiko;Sondermann, Philipp;Leopold-Messer, Stefan;Liu, Yizhou;Suo, Rei;Bhushan, Agneya;Vadakumchery, Lida;Greczmiel, Ute;Yashiroda, Yoko;Kimura, Hiromi;Nishimura, Shinichi;Hoshikawa, Yojiro;Yoshida, Minoru;Oxenius, Annette;Matsunaga, Shigeki;Williamson, R. Thomas;Carreira, Erick M.;Piel, Jorn. And the article was included in Nature Chemistry in 2022.Product Details of 7447-41-8 The following contents are mentioned in the article:
Host-associated bacteria are increasingly being recognized as underexplored sources of bioactive natural products with unprecedented chem. scaffolds. A recently identified example is the plant-root-associated marine bacterium Gynuella sunshinyii of the chem. underexplored order Oceanospirillales. Its genome contains at least 22 biosynthetic gene clusters, suggesting a rich and mostly uncharacterized specialized metabolism Here, in silico chem. prediction of a non-canonical polyketide synthase cluster has led to the discovery of janustatins, structurally unprecedented polyketide alkaloids with potent cytotoxicity that are produced in minute quantities. A combination of MS and two-dimensional NMR experiments, d. functional theory calculations of 13C chem. shifts and semiquant. interpretation of transverse rotating-frame Overhauser effect spectroscopy data were conducted to determine the relative configuration, which enabled the total synthesis of both enantiomers and assignment of the absolute configuration. Janustatins feature a previously unknown pyridodihydropyranone heterocycle and an unusual biol. activity consisting of delayed, synchronized cell death at subnanomolar concentrations [graphic not available: see fulltext] This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Product Details of 7447-41-8).
Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 7447-41-8
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics