Pinto, Jerrina et al. published their research in Biocatalysis and Agricultural Biotechnology in 2022 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C6H9ClO3

Substrate selectivity and kinetic studies of (S)-specific alcohol dehydrogenase purified from Candida parapsilosis ATCC 7330 was written by Pinto, Jerrina;Chadha, Anju;Gummadi, Sathyanarayana N.. And the article was included in Biocatalysis and Agricultural Biotechnology in 2022.Electric Literature of C6H9ClO3 The following contents are mentioned in the article:

Biocatalytic reduction catalyzed by alc. dehydrogenases is a valuable tool for asym. synthesis of chiral alcs. This study reports the broad substrate specificity of NADH dependent (S) – specific alc. dehydrogenase (S-ADH) purified from Candida parapsilosis ATCC 7330. The substrates for this enzyme include aliphatic and aromatic ketones, cyclic and diketones, aldehydes, ketoesters, primary and secondary alcs. The kinetic studies of different substrates indicate that ketones and secondary alcs. are the most preferred substrates of S-ADH with highest catalytic efficiencies reported for reduction of acetone (4153 s-1mM-1) and oxidation of 2-propanol (1358 s-1mM-1). The double reciprocal plots obtained for varied concentrations of acetophenone (0.2-16 mM) at a fixed concentration of NADH (0.05, 0.1 and 0.2 mM) and with varied concentrations of NADH (0.01-0.2 mM) at a fixed concentration of acetophenone (1, 4, 8 and 16 mM) showed intersecting lines indicating sequential kinetic mechanism. S-ADH follows Prelog’s stereopreference in reducing prochiral carbonyl substrates to yield (S)-alcs. with >99% enantiomeric excess using a simple coupled substrate approach for cofactor recycling. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Electric Literature of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics