Detection of intracellular lamellar bodies as a screening marker for fibrotic lesions was written by Park, Eun-Jung;Kang, Min-Sung;Lim, Hyun-Ji;Kang, Tae Kyu;Jin, Seung-Woo;Lee, Seung Hyeun;Baek, Sun Hwa;Kang, Jeong Won. And the article was included in Toxicology and Applied Pharmacology in 2021.Synthetic Route of C25H46ClN The following contents are mentioned in the article:
With the rapid increase in application of disinfectants worldwide as a method to block the spread of coronavirus, many new products are being introduced into the market without thorough verification of their impacts on human health and the environment. In the present study, we aimed to propose a screening marker for materials that can induce fibrotic lung disease using disinfectants, which had been demonstrated as causative materials of chronic inflammation and interstitial fibrosis. We first calculated the corresponding LC50 level based on results from cell viability test and exposed the LC50 level of disinfectants to human bronchial epithelial cells for 24 h. Formation of lamellar body-like structures, cleavage of the nuclear matrix, structural damage of mitochondria were found in the cytosol of the treated cells. We also dosed disinfectants by pharyngeal aspiration to mice to determine the LD0 level. The mice were sacrificed on Day 14 after a single dosing, and lamellar body-like structures were observed in the lung tissue of mice. Herein, we hypothesize that DNA damage and metabolic disturbance may play central roles in disinfectant-induced adverse health effects. Addnl., we propose that formation of lamellar bodies can be a screening marker for interstitial fibrosis. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Synthetic Route of C25H46ClN).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C25H46ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics