An efficient green approach for the synthesis of benzothiazole-linked pyranopyrazoles as promising pharmacological agents and docking studies was written by Mallikarjuna Reddy, Guda;Raul Garcia, Jarem;Venkata Subbaiah, Munagapati;Wen, Jet-Chau. And the article was included in Journal of Heterocyclic Chemistry in 2021.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Benzothiazole-tethered pyranopyrazoles derivatives I [R = H, 2-Cl, 4-O2N, etc.] were prepared via environmentally favorable conditions, which included eco-friendly catalyst, ethanol-water solvent, one-pot reaction, and atom- and step-economy procedures. Excellent yield of the products was observed Besides, all products were screened for their antimicrobial behavior. From the biol. results, it was seen that most of the compounds possessed high to moderate antimicrobial properties. Compound I [R = 2-Me] gave prominent antimicrobial property followed by I [R = H, 2-MeO, 4-HO]. In addition, computer-aided studies of the active compounds were also conducted. In this, selected compounds were docked into the intercalation site of DNA of the DNA-gyrase complex. From these results, the highest binding energy of -10.1 kcal/mol was for I [R = 2-Me] against DNA-gyrase. This is the first eco-friendly synthetic method for the preparation of benzothiazole-pyranopyrazoles and the synthetic effort in this study may serve as a model for addnl. environmentally benign reactions. The biol. results may prompt further studies related to antibiotic drugs. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics