Liu, Yaning et al. published their research in Youji Huaxue in 2017 | CAS: 2272-40-4

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 2272-40-4

Synthesis and bioactivities of multiheterocyclic molecules based on s-triazine was written by Liu, Yaning;Sun, Xiaona;Gao, Ran;Li, Chuanyin;Wang, Jing;Li, Yizheng;Zhang, Chenglu. And the article was included in Youji Huaxue in 2017.Related Products of 2272-40-4 The following contents are mentioned in the article:

S-triazine derivatives have good significant biol. activities. It has been an important method to develop novel drugs by introduction of other heterocyclic rings onto s-triazine. Twenty-one novel target mols. were designed and synthesized by combination of 1,2,4-triazole, triazole[3,4-b]thiadiazole and 1,2,4-triazine unit with s-triazine resp. The structures of the target mols. were characterized by IR, 1H NMR and HRMS. In order to study the effect of different substituents on the efficacy activities, first, 8 target mols. containing double 1,2,4-triazole unit were synthesized by the condensation of four different mono-substituted s-triazines with intermediates containing n-pentyl and benzyl, resp. Meanwhile, 4 target mols. were synthesized by the modification of the amino group. Nine target mols. were also afforded by the reaction of seven disubstituted s-triazines with the intermediates. The inhibitory activities of the 21 target mols. against Cdc25B were evaluated. The results showed that 13 target mols. exhibited good inhibitory activities against Cdc25B. The IC50 values were between (3.99±0.80) and (0.44±0.07) μg/mL, wherein the IC50 of 5 target mols. were lower than comparison reference Na3VO4, which were expected to be potential anticancer drugs. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics