Deep eutectic solvents as media in alcohol dehydrogenase-catalyzed reductions of halogenated ketones was written by Ibn Majdoub Hassani, Fatima Zohra;Amzazi, Saaid;Kreit, Joseph;Lavandera, Ivan. And the article was included in ChemCatChem in 2020.Computed Properties of C6H9ClO3 The following contents are mentioned in the article:
The application of deep eutectic solvents (DESs) in biotechnol. processes has gained an outstanding relevance, as they can be used as greener media to obtain higher productivities and selectivities. In the present contribution, an eutectic mixture composed of choline chloride (ChCl): glycerol (1 : 2 mol/mol) has been used as a reaction medium in combination with Tris-SO4 50 mM buffer pH 7.5, applied to the alc. dehydrogenase (ADH)-catalyzed reduction of various carbonyl precursors of chiral halohydrins. These alcs. are key intermediates of biol. active compounds, and hence they are of industrial interest. In the presence of up to 50% volume/volume of DES, these biotransformations were achieved up to 300-400 mM of the α-halogenated ketone substrate, getting access to the final compounds with excellent conversions (usually >90%) and enantiomeric excess (ee >99%). Among the different ADHs tested, two stereocomplementary enzymes (Lactobacillus brevis ADH and Rhodococcus ruber ADH) afforded the best results, so both alc. enantiomers could be obtained in all the studied examples. Selected bioredns. were scaled up to 250 mg and 1 g, demonstrating the potential that DESs can offer as media in redox processes for substrates with low solubility in water. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Computed Properties of C6H9ClO3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H9ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics