Stereospecific Synthesis of (Z,Z)-Isobenzofurans via Radical-Enabled Cleavage of C(sp3)-C(sp3) and C(sp2)-Halogen Bonds was written by Huang, Min-Hua;Shi, Hao-Nan;Zhu, Chi-Fan;He, Chun-Lan;Hao, Wen-Juan;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Advanced Synthesis & Catalysis in 2019.Related Products of 1186603-47-3 The following contents are mentioned in the article:
A novel radical-induced annulation/1,8-halosulfonylation of β-alkynyl ketones I (X = CH; R1 = Ph, 3-ClC6H4, 4-EtC6H4, etc.; R2 = H, 5-F, 4-Cl, 5-Cl, 5-MeO) and I (X = N; R1 = 4-ClC6H4; R2 = H) with haloaryl diazonium tetrafluoroborates X1C6H4N2+BF4– (X1 = 4-Cl, 4-Br, etc.) and DABCO·bis(sulfur dioxide) was first achieved via the cleavage/recombination of C(sp3)-C(sp3) and C(sp2)-halogen bonds, from which 47 examples of sulfone-containing 1,3-dimethylene-substituted (Z,Z)-isobenzofurans II as single stereoisomers were synthesized in generally good yields. This multicomponent pathway is proposed to proceed through the in-situ generation of arylsulfonyl radicals, followed by selective radical addition-cyclization and ring-opening of the cyclopropyl unit as well as C(sp2)-halogen bond cleavage, resulting in the consecutive construction of three new chem. bonds, including C-S, C-O and C-halogen bonds. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Related Products of 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics