Goud, Nerella Sridhar et al. published their research in Chemical Biology & Drug Design in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of Ethyl 4-chloro-3-oxobutanoate

Synthesis and biological evaluation of morpholines linked coumarin-triazole hybrids as anticancer agents was written by Goud, Nerella Sridhar;Pooladanda, Venkatesh;Mahammad, Ghouse S.;Jakkula, Pranay;Gatreddi, Santhosh;Qureshi, Insaf A.;Alvala, Ravi;Godugu, Chandraiah;Alvala, Mallika. And the article was included in Chemical Biology & Drug Design in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

A series of novel morpholines linked coumarin-triazole hybrids (6a-6v) has been synthesized and evaluated for their anti-proliferative potential on a panel of five human cancer cell lines, namely bone (MG-63), lung (A549), breast (MDA-MB-231), colon (HCT-15) and liver (HepG2), using MTT assay. Among all, the compound 6n {7-((1-(2,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl) methoxy)-4-((2,6-dimethylmorpholino) methyl)-2H-chromen-2-one} showed significant growth inhibition against MG-63 cells with an IC50 value of 0.80 ± 0.22μM. Further, induction of apoptosis by 6n of MG-63 cells confirmed as a result of morphol. changes, the sub-G1 phase arrest, increased percentage of apoptotic cells, and decrease in mitochondrial membrane potential and increase in reactive oxygen species levels. The in vitro Gal-1 expression in cell culture supernatant of MG-63 cells treated with compound 6n showed dose-dependent reduction The binding constant (Ka) of 6n with Gal-1 was calculated from the intercept value which was observed as 3.0 × 105 M-1 by fluorescence spectroscopy. Surface plasmon resonance showed that 6n binds to Gal-1 with binding constant (Ka) of 1.29E+04 1/Ms and equilibrium constant KD value of 7.54E-07 M, resp. Mol. docking studies revealed the binding interactions of 6n with Gal-1. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics