Facile synthesis of carbon-11-labeled arylpiperazinylthioalkyl derivatives as new PET radioligands for imaging of 5-HT1AR was written by Gao, Mingzhang;Wang, Min;Zheng, Qi-Huang. And the article was included in Applied Radiation and Isotopes in 2012.SDS of cas: 6294-17-3 The following contents are mentioned in the article:
Carbon-11-labeled arylpiperazinylthioalkyl derivatives, 2-((4-(4-(2-[11C]methoxyphenyl)piperazin-1-yl)butyl)thio)benzo[d]oxazole ([11C]5a), 2-((4-(4-(2-[11C]methoxyphenyl)piperazin-1-yl)butyl)thio)-5,7-dimethylbenzo[d]oxazole ([11C]5c), 2-((4-(4-(2-[11C]methoxyphenyl)piperazin-1-yl)butyl)thio)benzo[d]thiazole ([11C]5e), 2-((6-(4-(2-[11C]methoxyphenyl)piperazin-1-yl)hexyl)thio)benzo[d]oxazole ([11C]5g), 2-((6-(4-(2-[11C]methoxyphenyl)piperazin-1-yl)hexyl)thio)-5,7-dimethylbenzo[d]oxazole ([11C]5i), and 2-((6-(4-(2-[11C]methoxyphenyl)piperazin-1-yl)hexyl)thio)benzo[d]thiazole ([11C]5k), were prepared from their corresponding phenol precursors with [11C]CH3OTf through O-[11C]methylation and isolated by a simplified solid-phase extraction (SPE) method using a Sep-Pak Plus C18 cartridge in 50-60% (n=5) radiochem. yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 23 min, the radiochem. purity was >99%, and the specific activity at end of synthesis (EOS) was 277.5±92.5 GBq/μmol (n=5). This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics