Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains was written by Bi, Fangchao;Song, Di;Qin, Yinhui;Liu, Xingbang;Teng, Yuetai;Zhang, Na;Zhang, Panpan;Zhang, Nan;Ma, Shutao. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
The spread of infections caused by multidrug-resistant (MDR) pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), has created a need for new antibiotics with novel mechanisms of action. The bacterial division protein FtsZ has been identified as a novel drug target that can be exploited clin. As part of an ongoing effort to develop FtsZ-targeting antibacterial agents, we describe herein the design, synthesis and bioactivity of six series of novel 1,3,4-oxadiazol-2-one-containing, 1,2,4-triazol-3-one-containing and pyrazolin-5-one-containing benzamide derivatives Among them, the most potent antibacterial agent was identified and was much better than clin. drugs such as ciprofloxacin, linezolid, and erythromycin against all the tested gram-pos. strains, particularly methicillin-resistant, penicillin-resistant and clin. isolated S. aureus. Subsequent studies on biol. activities and docking analyses proved that it functioned as an effective compound targeting FtsZ. Preliminary SAR indicated a general direction for further optimization of these novel analogs. Taken together, this research provides a promising chemotype for developing newer FtsZ-targeting bactericidal agents. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Category: chlorides-buliding-blocks).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics