Synthesis, characterization, anti-bacterial and anticancer activities of Palladium(II) mixed ligand complexes of 2-mercapto-5-methyl-1,3,4-thiadiazole (HmtzS) and phosphines. Crystal structure of [Pd(mtzS)2(dppf)].H2O.EtOH was written by Al-Mouqdady, Omar D. H.;Al-Janabi, Ahmed S.;Hatshan, Mohammad R.;Al-Jibori, Subhi A.;Fiahan, Ahmed S.;Wagner, C.. And the article was included in Journal of Molecular Structure in 2022.COA of Formula: Cl4Na2Pd The following contents are mentioned in the article:
Two thione and thionate based complexes were synthesized by simply reacting the ligand 2-mercapto-5-methyl-1,3,4-thiadiazole (HmtzS) with palladium(II) salt in a neutral or basic medium in 2:1 molar ratio. Reacting of resulting complex [Pd(mtzS)2] (2) with Ph2P(CH2)nPPh2 (n = 1-4), dppf, Ph3P or Ph3PS yielded mononuclear complexes, [Pd(mtzS)2(Ph2P(CH2)nPPh2)] (3–5), [Pd(mtzS)2(dppf)] (6), [Pd(mtzS)2(Ph3P)2] (7) or [Pd(mtzS)2(Ph3PS)2] (8). An x-ray structure of [Pd(mtzS)2(dppf)] (6) shows that the mtzS ligand is now coordinated in a monodentate fashion via the sulfur atom. The prepared complexes were screened against Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aurous, Escherichia coli and S. typhi. Also the cytotoxicity of the prepared complexes were evaluated against colon mammalian cancer (LoVo) and breast cancer (MCF-7) cell lines by MTT assay. Complexes exhibited cytotoxicity with IC50 values within (9.7 ± 1.2) to (39.1 ± 7.6) μM range against LoVo and within (8.8 ± 1.4) to (40.2 ± 2.6) μM range against MCF-7 cell lines. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6COA of Formula: Cl4Na2Pd).
Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: Cl4Na2Pd
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics