Role of the ancillary ligand in determining the antimicrobial activity of Pd(II) complexes with N-N-N-tridentate coligand was written by Mansour, Ahmed M.;Radacki, Krzysztof;Shehab, Ola R.. And the article was included in Polyhedron in 2022.Application of 13820-53-6 The following contents are mentioned in the article:
Two [PdN3L]PF6 complexes (L = 2,6-bis(1-ethyl-benzimidazol-2-yl)pyridine (L-BZ) and 4-(2-pyridyl)-2,2′:6′,2”-terpyridine (L-PY)) underwent catalyst-free 1,3-dipolar cycloaddition coupling with Ph isothiocyanate at the room temperature giving the corresponding tetrazole-thiolato complexes. 1H NMR studies showed that the N1-isomer appeared first in the catalyst-free coupling, then gradually isomerized to the more stable tetrazole-thiolato isomer. The interconversion of N1-isomer into the S-isomer is accompanied by a decrease of the greater steric demand of the 5-membered ring. Tetrazolate complex of L-BZ displayed higher antifungal activity (MIC ≤ 0.25μg/mL) than the chloride analog (MIC = 0.5-1.0μg/mL) and the reference drug, Fluconazole (MIC = 0.125-8.0μg/mL) against Candida albicans and Cryptococcus neoformans. The treated non-cancerous human embryonic kidney cells (HEK293) showed no cytotoxicity and no haemolysis release at the measured concentrations of the chloride complex of L-BZ and tetrazolate complex of L-PY. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6Application of 13820-53-6).
Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 13820-53-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics