Influence of serum concentration and surface functionalization on the protein adsorption to mesoporous silica nanoparticles was written by Lin, Chih-Yu;Yang, Chia-Min;Linden, Mika. And the article was included in RSC Advances in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
A study of a protein corona on mesoporous silica nanoparticles (MSNs) at in vitro and in vivo relevant serum concentrations is presented. Three MSNs different in terms of mesoscopic pore arrangement, surface chem. and surface roughness were studied. After incubation in either 10% or 100% serum, the hard protein corona-particle complexes were collected and analyzed by DLS, zeta-potential, and TGA, and the corona proteins were analyzed with SDS-PAGE. A good correlation between SDS-PAGE and TG results in terms of total amounts of proteins adsorbed was established. The results demonstrated that more proteins, especially apolipoproteins, were associated with the particles at higher serum concentration regardless of surface chem. and morphol. differences. Also, the mean mol. weight of the adsorbed proteins was clearly lower under full serum conditions modeling in vivo conditions as compared to under dilute conditions modeling in vitro conditions, but functionalization of the MSNs by carboxylic acid functionalities reduced protein adsorption. The influence of the structural characteristics of the MSNs on the protein adsorption was minor. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Category: chlorides-buliding-blocks).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics