Design, synthesis, and application of a protein A mimetic was written by Li, Rongxiu;Dowd, Victor;Stewart, David J.;Burton, Stephen J.;Lowe, Christopher R.. And the article was included in Nature Biotechnology in 1998.Electric Literature of C9H6Cl2N4 The following contents are mentioned in the article:
Low-mol.-weight synthetic mols. that mimic the activity of native biol. macromols. have therapeutic potential, utility in large-scale production of biopharmaceuticals, and the capacity to act as probes to study mol. recognition events. The authors have developed a nonpeptidyl mimic for Staphylococcus aureus Protein A (SpA). The specific recognition and complexation elements between the B domain (Fb) of SpA and the Fc fragment of IgG were identified from the x-ray crystallog. structure. Computer-aided mol. modeling was used to design a series of biomimetic mols. around the Phe 132-Tyr133 dipeptide involved in its binding to IgG. One of the ligands binds IgG competitively with SpA in solution and when immobilized on agarose beds, with an affinity constant of 105-106 M-1. The immobilized artificial Protein A was used to purify IgG from human plasma and murine IgG from ascites fluid, and to remove bovine IgG from fetal calf serum. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Electric Literature of C9H6Cl2N4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C9H6Cl2N4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics