Kuthyala, Sharanya et al. published their research in ChemistrySelect in 2021 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C6H9ClO3

Towards the Synthesis of Imidazopyridine Derivatives: Characterization, Single Crystal XRD, Hirshfeld Analysis, and Biological Evaluation was written by Kuthyala, Sharanya;Sheikh, Sareen;Nagaraja, G. K.;Kannika, B. R.;Madan Kumar, S.;Chandra Nayak, S.;Lokanath, N. K.. And the article was included in ChemistrySelect in 2021.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

This study explores the synthesis of different imidazopyridine derivatives, their characterization, single crystal x-ray diffraction, mol. Hirshfeld surface anal. along with their anticancer and other supportive biol. evaluations. X-ray crystallog. study resolved the crystal structure of 2,7-dimethyl-N-(1,3-dioxoisoindolin-2-yl)H-imidazo[1,2-a]pyridine-3-carboxamide as monoclinic crystal system (space group P21/n). Graphical tool, Hirshfeld surface anal. quantified the major contribution of H···H, O···H, and C···H interactions towards the HS. Among the synthesized compounds, 2-(4-(4-fluorophenyl)-5-(2,8-dimethyl-imidazo[1,2-a]pyridin-3-yl)-4H-1,2,4-triazol-3-ylthio)-N-(4-fluorophenyl)acetamide exhibited the highest cytotoxicity against lung adenocarcinoma with IC50 value of 43.04μM. Selective action of I was assured by cell death anal. using AO-EB assay. In addition, the study was also supported by mol. docking studies. Together the study revealed, the compound I to be a likely candidate for further exploratory study in cancer treatment. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics