Pharmacological and Molecular docking studies of new copper (II) complexes of N2-Phenyl-N4,N6-di(thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine was written by Vathanaruba, M.;Raja, S. Johnson;Princess, R.;Tharmaraj, P.. And the article was included in Journal of Molecular Structure in 2022.Related Products of 2272-40-4 The following contents are mentioned in the article:
Cu(II) complexes of tri substituted 1,3,5 triazine based ligand (PDTTA) N2-Phenyl-N4,N6-di(thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine were synthesized. The structural features of the ligand and its metal complexes were characterized by micro anal. data, magnetic susceptibility measurements, molar conductance, IR, UV-Visible, 1HNMR, Mass and EPR spectral techniques. The nonelectrolytic behavior of the complexes was confirmed from their conductance data. The electrochem. behavior of the complexes was studied by cyclic voltammetry. The free ligand and its metal complexes were screened for their in vitro biol. activity against bacteria Staphylococcus aureus and Escherichia coli and the fungi Candida albicans and Aspergillus niger by well diffusion method. The free ligand and the Cu(II) complexes were screened for in vivo anticonvulsant activity by maximal electroshock method and showed significant activity. Carrageenan induced rat paw edema is the most widely used primary test to screen inflammation which measures the ability of the compounds to reduce local edema induced in the rat paw by carrageenan. The ligand and Cu[(PDTTA)(ac)2] are identified as a new lead structure, demonstrated antiinflammatory properties in preliminary studies in mice. Mol. docking study was conducted to study the mol. mechanism of antiinflammatory activity. Cu[(PDTTA)(ac)2] is potent inhibitor of PDE4 enzyme which is involved in the inflammation process. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics