Air and surface sampling method for assessing exposures to quaternary ammonium compounds using liquid chromatography tandem mass spectrometry was written by LeBouf, Ryan F.;Virji, Mohammed Abbas;Ranpara, Anand;Stefaniak, Aleksandr B.. And the article was included in Annals of Work Exposures and Health in 2017.Reference of 122-18-9 The following contents are mentioned in the article:
This method was designed for sampling select quaternary ammonium (quat) compounds in air or on surfaces followed by anal. using ultraperformance liquid chromatog. tandem mass spectrometry. Target quats were benzethonium chloride, didecyldimethylammonium bromide, benzyldimethyldodecylammonium chloride, benzyldimethyltetradecylammonium chloride, and benzyldimethylhexadecylammonium chloride. For air sampling, polytetrafluoroethylene (PTFE) filters are recommended for 15-min to 24-h sampling. For surface sampling, Pro-wipe 880 (PW) media was chosen. Samples were extracted in 60:40 acetonitrile:0.1% formic acid for 1 h on an orbital shaker. Method detection limits range from 0.3 to 2 ng/mL depending on media and analyte. Matrix effects of media are minimized through the use of multiple reaction monitoring vs. selected ion recording. Upper confidence limits on accuracy meet the National Institute for Occupational Safety and Health 25% criterion for PTFE and PW media for all analytes. Using PTFE and PW analyzed with multiple reaction monitoring, the method quantifies levels among the different quats compounds with high precision (<10% relative standard deviation) and low bias (<11%). The method is sensitive enough with very low method detection limits to capture quats on air sampling filters with only a 15-min sample duration with a maximum assessed storage time of 103 days before sample extraction This method will support future exposure assessment and quant. epidemiol. studies to explore exposure-response relationships and establish levels of quats exposures associated with adverse health effects. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Reference of 122-18-9).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 122-18-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics