Black phosphorus-assisted laser desorption ionization mass spectrometry for the determination of low-molecular-weight compounds in biofluids was written by He, Xiao-Mei;Ding, Jun;Yu, Lei;Hussain, Dilshad;Feng, Yu-Qi. And the article was included in Analytical and Bioanalytical Chemistry in 2016.COA of Formula: C25H46ClN The following contents are mentioned in the article:
Quant. anal. of small mols. by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been a challenging task due to matrix-derived interferences in low m/z region and poor reproducibility of MS signal response. The authors developed an approach by applying black phosphorus (BP) as a matrix-assisted laser desorption ionization (MALDI) matrix for the quant. anal. of small mols. for the first time. Black phosphorus-assisted laser desorption/ionization mass spectrometry (BP/ALDI-MS) showed clear background and exhibited superior detection sensitivity toward quaternary ammonium compounds compared to carbon-based materials. By combining stable isotope labeling (SIL) strategy with BP/ALDI-MS (SIL-BP/ALDI-MS), a variety of analytes labeled with quaternary ammonium group were sensitively detected. Moreover, the isotope-labeled forms of analytes also served as internal standards, which broadened the analyte coverage of BP/ALDI-MS and improved the reproducibility of MS signals. Based on these advantages, a reliable method for quant. anal. of aldehydes from complex biol. samples (saliva, urine, and serum) was successfully established. Good linearities were obtained for five aldehydes at 0.1-20.0 μM with correlation coefficients (R2) larger than 0.9928. The LODs are 20 to 100 nM. Reproducibility of the method was obtained with intra-day and inter-day relative standard deviations (RSDs) <10.4 %, and the recoveries in saliva samples ranged from 91.4 to 117.1%. Taken together, the proposed SIL-BP/ALDI-MS strategy proved to be a reliable tool for quant. anal. of aldehydes from complex samples. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9COA of Formula: C25H46ClN).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C25H46ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics