Effect of chronic lithium on mechanical sensitivity and trabecular bone loss induced by type-1 diabetes mellitus in mice was written by Graniel-Amador, Mayra Alejandra;Torres-Rodriguez, Hector Fabian;Martinez-Mendoza, Ruth Elena;Vargas-Munoz, Virginia Margarita;Acosta-Gonzalez, Rosa Issel;Castaneda-Corral, Gabriela;Munoz-Islas, Enriqueta;Jimenez-Andrade, Juan Miguel. And the article was included in BioMetals in 2022.Product Details of 7447-41-8 The following contents are mentioned in the article:
Type-1 diabetes mellitus (T1DM) is a chronic condition characterized by long-term hyperglycemia that results in several complications such as painful peripheral neuropathy, bone deterioration, and increased risk of bone fractures. Lithium, a first-line therapy for bipolar disorder, has become an attractive agent for attenuating peripheral neuropathy and menopause-induced bone loss. Therefore, our aim was to determine the effect of chronic lithium treatment on mech. hypersensitivity and trabecular bone loss induced by T1DM in mice. T1DM was induced in male C57BL/6J mice by i.p. injection of streptozotocin (STZ, 50 mg/kg/day, for 5 consecutive days). 12 wk after T1DM-induction, mice received a daily i.p. injection of vehicle, 30 or 60 mg/kg lithium (as LiCl) for 6 wk. Throughout the treatment period, blood glucose levels and mech. sensitivity were evaluated every 2 wk. After lithium treatment, the femur and L5 vertebra were harvested for microcomputed tomog. (microCT) anal. T1DM mice showed significant hyperglycemia, mech. hypersensitivity, and significant trabecular bone loss as compared with the control group. Chronic lithium treatment did not revert the hindpaw mech. hypersensitivity nor hyperglycemia associated to T1DM induced by STZ. In contrast, microCT anal. revealed that lithium reverted, in a dose-dependent manner, the loss of trabecular bone associated to T1DM induced by STZ at both the distal femur and L5 vertebra. Lithium treatment by itself did not affect any trabecular bone parameter in non-diabetic mice. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Product Details of 7447-41-8).
Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 7447-41-8
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics