Simultaneous determination of lobetyolin and atractylenolide III in Codonopsis Radix by dispersive liquid-liquid microextraction based on hydrophobic deep eutectic solvent was written by Bai, Yun-e;Zhang, Xiao-ting;Zhang, Rui-ming;Hou, Jing;Niu, Yuan-jing;Hu, Shuang;Gao, Jian-ping. And the article was included in Microchemical Journal in 2021.Product Details of 5137-55-3 The following contents are mentioned in the article:
In order to achieve the determination and quantification of trace lobetyolin and atractylenolide III in Codonopsis Radix, a procedure of dispersive liquid-liquid microextraction utilizing a hydrophobic deep eutectic solvent as the extractant combined with high performance liquid chromatog. was developed. The primary variables affecting the extraction process, including the type, ratio and volume of extractant, pH and salt concentration in sample phase, type and volume of dispersant, extraction time, centrifugal speed and time were optimized. In this experiment, the deep eutectic solvent prepared by methyltrioctylammonium chloride and n-butanol was the best extractant. The both target analytes showed good linearity (r2 > 0.990) in their resp. linear ranges (0.01-2.5μg/mL and 0.009-2.0μg/mL). And the limits of detection and quantification were 6 × 10-4 and 2 × 10-3 μg/mL for lobetyolin, 3 × 10-3 and 9 × 10-3 μg/mL for atractylenolide III. The enrichment factors were 37 for lobetyolin and 154 for atractylenolide III resp. The relative standard deviations of precision were 1.2-6.4% and the spiked recovery values were in the range of 87.6-114.7% with the relative standard deviations of 1.5-4.7%. It is successful to objectively and clearly distinguish the three origins of Codonopsis Radix by comparing the contents of the both analytes with proposed method. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Product Details of 5137-55-3).
N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 5137-55-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics