Association, distribution, liberation, and rheological balances of alkyldimethylbenzylammonium chlorides (C12-C16) was written by Vitkova, Zuzana;Oremusova, Jarmila;Herdova, Petra;Ivankova, Ol’ga;Vitko, Anton. And the article was included in Molecules in 2017.COA of Formula: C25H46ClN The following contents are mentioned in the article:
It is known that cationic surfactants have an antimicrobial effect and act as enhancers. This paper studies three cationic surfactants from the group of alkyldimethylbenzylammonium chlorides (dodecyl-, tetradecyl-, and hexadecyl). Interest is focused on the association of the surfactants with respect to temperature, partition balances and their influence on drug release, rheol. properties, and the pH of hydrogels. The critical micelle concentrations (CMC) of the surfactants were estimated from dependencies of conductivity, d., spectrofluorimetry, and UV-VIS spectrophotometry on molarity in the temperature range of 25-50°C. It was found that the temperature dependence of a CMC is U-shaped, with its min. at 30°C, and the CMC value decreases as the length of the chain increases. The pseudo-phase separation model was used for the calculation of various thermodn. parameters, such as the Gibbs free energies (spontaneous process), enthalpies (exothermic process), and entropies of the micelles’ formation, CMCs, and the degree of counterion binding. All thermodn. parameters, as functions of the temperature, were estimated It was found that partition coefficients increase as the length of the alkyl chain and the pH = (5.0-7.0) increase. The influences of surfactants, below and above the CMC, on drug (chlorhexidine dihydrochloride) release from hydrogels, rheol. properties, and pH at 30°C were studied. Also, the amounts of the released drug increase as the alkyl chains of the surfactants prolongate. The amounts of the released drug with the surfactant below the CMC are greater than that above the CMC. All hydrogels (regardless of the length of the alkyl chain) exhibit a non-Newtonian pseudo-plastic flow. The results obtained will be used in the formulation of the drug and surfactants into dosage forms. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9COA of Formula: C25H46ClN).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C25H46ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics