Presa, Andreu published the artcileNon-Switching 1,2-Dithienylethene-based Diplatinum(II) Complex Showing High Cytotoxicity, Related Products of chlorides-buliding-blocks, the publication is Inorganic Chemistry (2016), 55(11), 5356-5364, database is CAplus and MEDLINE.
A diplatinum(II) complex was prepared from a new 1,2-dithienyl-ethene-based ligand containing N-methylimidazole groups as metal-binding units. Reaction of the ligand 1,2-bis[2-methyl-5-(1-methyl-1H-imidazol-2-yl)-3-thienyl]-cyclopentene (L2H) with cis-dichlorobis(dimethylsulfoxido)platinum(II) generated the bimetallic complex trans-[Pt2Cl4(DMSO)2(L2H)] (1), whose DNA-interacting properties were studied using different techniques. Cytotoxicity assays with various cancer cell lines showed that this compound is active, with IC50 values in the micromolar range. Surprisingly, the diplatinum(II) complex does not exhibit the anticipated photoswitching properties; indeed, UV irradiation does not lead to the photocyclization of the ligand L2H or of the metal complex. Computational studies were performed and revealed significant differences in the electronic structure of L2H compared with L1H (i.e., 1,2-bis[2-methyl-5-(4-pyridyl)-3-thienyl]-cyclopentene, which exhibits photoswitching properties), in terms of the relevant MOs involved in the UV-visible absorption features, which ultimately is responsible for the inertia of L2H toward photocyclization.
Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Related Products of chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics