Pal, Manojit published the artcileSynthesis of fused sulfonamide (1,1-dioxoisothiazole)-substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is pyrazole benzoisothiazolyl aryl preparation cyclooxygenase inhibitor.
First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted arylpyrazoles, e.g., I, has been accomplished via oxidative cyclization of 4-fluoro-2-Me benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbonyl compounds A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biol. interest. In studies evaluating cyclooxygenase inhibiting activity, I was found to be more than 100 fold selective in COX-2 inhibition over COX-1.
Journal of the Indian Chemical Society published new progress about Homo sapiens. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics