Nencini, Arianna published the artcileDesign and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor, Category: chlorides-buliding-blocks, the main research area is SAR preparation alpha 7 nicotinic acetylcholine receptor agonist preparation; drug design mol docking chem library preparation; Alzheimer’s disease; Cognition; Neuronal nicotinic acetylcholine receptors; Nicotinic ligands; Schizophrenia.
α7 Nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chem. program we investigated a novel series of α7 nAChR agonists. Starting from mol. docking studies on two series of mols. recently developed in our laboratories, an alternative scaffold was designed attempting to combine the optimal features of these previously identified urea and pyrazole compounds Based on our previous SAR knowledge and on predicted drug-like properties, a small library was synthesized in parallel manner, affording compounds with excellent α7 nAChR activity, selectivity and preliminary ADME profile.
European Journal of Medicinal Chemistry published new progress about Chemical library. 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, Category: chlorides-buliding-blocks.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics