Madaiah, Malavalli published the artcileSynthesis and Pharmacological Evaluation of Novel 1′-[2-(Difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-diones and Their Derivatives, Related Products of chlorides-buliding-blocks, the main research area is difluoromethoxyphenylmethyl spiro azabicyclooctane imidazolidine preparation anticonvulsant; Anticonvulsant; Isocyanate; Maximal electroshock; ScPTZ; Spirohydantoins.
A series of novel 1′-[2-(difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione substituted hydantoins was synthesized using an appropriate synthetic route and characterized by elemental anal. and spectral data. The novel mols. were screened for anticonvulsant activity in mice by maximal electroshock (MES) and s.c. pentylenetetrazol (ScPTZ)-induced seizure tests. The neurotoxicity was assessed using the rotarod method. Several compounds exhibited anticonvulsant activity in an MES seizure model and in a ScPTZ model, with lower neurotoxicity. Some title compounds showed lower central nervous system depression compared to phenytoin. The synthesis of the target compounds was achieved by a reaction of [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione with arenesulfonyl chlorides or aryl isocyanates. The title compounds thus formed included [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione sulfonamide analogs , such as a 4-fluoro-2-methylbenzenesulfonamide analog (I) and [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione amide analogs.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Related Products of chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics