Madaiah, M. published the artcileSynthesis and structure-activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is diazaspirodecanedione amino fluorophenoxyethyl preparation anticonvulsant.
A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives was synthesized and their pharmacol. activity was determined with the objective to better understand their structure-activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) test and their neurotoxic effects were determined by rotarod test. Majority of the compounds were active in MES tests. Compounds I [R = 4-MeC6H4NHCO, 3-MeC6H4NHCO, 2-CF3C6H4NHCO] showed a significant and protective effect on seizure, when compared with standard drug phenytoin. The compounds having an amide bond showed moderate protective effect on MES induced seizures compared to sulfonamide.
Medicinal Chemistry Research published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics