Gozde Gunduez, Miyase published the artcileSubstituted 9-aryl-1,8-acridinedione derivatives and their effects on potassium channels, Product Details of C8H4ClF3O, the main research area is acridinedione derivative SAR preparation potassium channel opener.
In this study, 12 new 3,6-dimethyl-9-aryl-3,4,6,7-tetrahydroacridine-1,8(2H,5H,9H,10H)-diones derivatives were synthesized. Synthesis of the compounds was realized by the reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehyde, and ammonium acetate in methanol. The structure of the compounds was elucidated by IR, 1H-NMR, 13C-NMR, mass spectroscopy, and elemental anal. Functional effects of the compounds on vascular potassium channels and mechanism of phenylephrine-induced contractile responses were investigated in isolated rat aorta rings. Pinacidil was used as a standard potassium channel opener.
Medicinal Chemistry Research published new progress about Hypertension. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Product Details of C8H4ClF3O.
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