Ruchelman, Alexander L. published the artcileIsosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity, HPLC of Formula: 99585-12-3, the main research area is dioxopiperidinyl isoindolinone isoindoledione preparation antitumor antiinflammatory agent; structure dioxopiperidinyl isoindolinone isoindoledione inhibition TNF alpha; antitumor immunomodulation activity dioxopiperidinyl isoindolinone isoindoledione; bioavailability dioxopiperidinyl isoindolinone isoindoledione TNF alpha inhibitor.
Dioxopiperidinyl isoindolinones such as I (R = Cl, Me) and dioxopiperidinyl isoindolediones were prepared as analogs of the immunomodulary drugs lenalidomide and pomalidomide for potential use as antiinflammatory and antitumor agents. I (R = Me) and I (R = Cl), resp., displayed potent inhibition of tumor necrosis factor-α (TNF-α) in lipopolysaccharide-stimulated human peripheral blood mononuclear cells, potent stimulation of IL-2 in a human T cell co-stimulation assay, and anti-proliferative activity against Namalwa human lymphoma cells. I (R = Cl, Me) were orally bioavailable in rats.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, HPLC of Formula: 99585-12-3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics