Lee, Hyu Ji published the artcileIsoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to β-amyloid fibrils, HPLC of Formula: 99585-12-3, the main research area is isoindoledione derivative preparation amyloid fibril binding Alzheimer diagnostic probe; isoindolone derivative preparation amyloid fibril binding Alzheimer diagnostic probe; lactam aryl preparation amyloid fibril binding Alzheimer diagnostic probe; cyclic imide preparation amyloid fibril binding Alzheimer diagnostic probe.
Based on the structural features of Indoprofen and PIB, a series of isoindol-1,3-diones and isoindol-1-ones were designed and synthesized. These 23 compounds were evaluated by competitive binding assay against aggregated Aβ42 fibrils using [125I]TZDM. All the isoindolone derivatives showed very good binding affinities with Ki values in the subnanomolar range (0.42-0.94 nM). Among them, isoindol-1,3-diones (I, R1 = Br, R2 = Me2N, R3 = MeO; R1 = H, R2 = MeO, R3 = Me2N) and isoindol-1-ones (II, R4 = F, R5 = R7 = H, R6 = Me2N; R4 = H, R5 = Me, R6 = Me2N, R= MeO) exhibited excellent binding affinities (Ki = 0.42-0.44 and 0.46-0.49 nM), resp., than those of Indoprofen (Ki = 0.52 nM) and PIB (Ki = 0.70 nM). These results suggest that isoindolones could be served as a scaffold for potential AD diagnostic probes to monitor Aβ fibrils.
Bioorganic & Medicinal Chemistry Letters published new progress about Alzheimer disease. 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, HPLC of Formula: 99585-12-3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics