Di Matteo, Mauro published the artcileSynthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors, Category: chlorides-buliding-blocks, the main research area is imidazolylmethylpiperidine sulfonamide preparation aromatase inhibitor; Anticancer agents; Aromatase inhibitor; Imidazole; Sulfonamide; Synthesis.
The most frequently used treatment for hormone receptor pos. breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC50 values that are similar to that of letrozole and SYN 20028567 were identified.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Category: chlorides-buliding-blocks.
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Chlorides – an overview | ScienceDirect Topics