Aswathanarayanappa, Chandrashekar published the artcileSynthesis, invitro and invivo anti-hyperglycemic activity of 1,2,4-triazolebenzylidene and 1,3,4-thiadiazole derivatives, Safety of Methyl 4-chloro-2-methylbenzoate, the main research area is benzylideneamino triazolethiol diastereoselective preparation antihyperglycemic antioxidant SAR; aminotriazolethiol aryl aldehyde; triazolothiadiazole preparation antihyperglycemic antioxidant SAR; aryl carboxylic acid aminotriazolethiol cyclocondensation.
New series of 1,2,4-triazole based Schiff bases I [R1 = H, 2-F, 4-OH, etc.] and 1,3,4-thiadiazole derivatives II [R2 = 2-Br-4-F, 2,6-CH3, 3-Br-5-I, etc.] were synthesized by utilizing 4-amino-5-(4-chloro-2-methylphenyl)-4H-1,2,4-triazole-3-thiol as active intermediate and evaluated for invitro anti-hyperglycemic activity by α-glucosidase enzyme inhibition and invivo by streptozotocin(STZ) and nicotinamide induced T2DM rat model. The compounds I [R1 = H, 2-F, 3-F, 2,5-OH, 4-OH, 4-OCH3] which showed potential DPPH radical scavenging activity with a level of inhibition ranging between 70% and 90% were considered for anti-hyperglycemic activity. The structure activity relationship studies revealed that the compounds I [R1 = 4-OH, 2,5-OH] showed good antioxidant property.
International Journal of PharmTech Research published new progress about Antidiabetic agents. 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, Safety of Methyl 4-chloro-2-methylbenzoate.
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