Gopal Hegde, Subramanya published the artcileRegioselective synthesis and biological evaluation of novel dispiropyrrolidine derivatives via one-pot four-component reaction, COA of Formula: C13H9ClO2, the main research area is sarcosine barbituric acid ninhydrin benzaldehyde magnesium silicate four component; dispiro indeno pyrrolidine pyrimidine pentaone regioselective preparation microwave irradiation; antitumor antibacterial activity SAR.
A new series of regioselective dispiropyrrolidine analogs I [Ar = Ph, 4-pyridinyl, 2-methyl-4-chlorophenyl, etc] via efficient one-pot four-component tandem reaction was discovered. The reaction was carried out in the presence of four common reactants and magnesium silicate nanoparticles (NPs) in ethanol under microwave irradiation The reaction proceeded rapidly and was completed within 60-90 min. This methodol. offered several significant advantages such as high yield, mild catalyst and easy to perform. The synthesized compound was further screened for antibacterial and antiproliferative activities. The results showed that compound I [Ar = 4-nitrophenyl, phenyl] were potent antibacterials against Gram-pos. and Gram-neg. bacteria. Further, compound I [Ar = phenyl] showed best antiproliferative activity against tested cell lines.
Synthetic Communications published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, COA of Formula: C13H9ClO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics