Xu, Rui published the artcileDiscovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA, HPLC of Formula: 7079-48-3, the main research area is spirocyclic sulfonamide preparation Akt inhibitor SAR.
We describe the design and synthesis of novel bicyclic spiro sulfonamides, e.g. I, as potent Akt inhibitors. Through structure-based rational design, we have successfully improved PKA selectivity of previously disclosed spirochromanes. Representative compounds showed favorable Akt potency while exhibiting up to 1000-fold selectivity against PKA.
Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, HPLC of Formula: 7079-48-3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics