Li, Ya published the artcileRemote γ-C(sp3)-H Alkylation of Aliphatic Carboxamides via an Unexpected Regiodetermining Pd Migration Process: Reaction Development and Mechanistic Study, Category: chlorides-buliding-blocks, the main research area is remote alkylation aliphatic carboxamide strained bicyclic alkene palladium catalyst.
In the presence of accessible β-C-H bonds, γ-C-H activation of saturated aliphatic carboxamides remains unresolved because β-C-H activation is kinetically favored. This is almost a dogma in the development of C-H activation reactions. Here we report a strategy to change this dogma, as we have found that a Pd-catalyzed, ligand-enabled remote γ-alkylation of saturated aliphatic carboxamides can be realized in the presence of more accessible β-C-H bonds by using strained bicyclic alkenes as the coupling partners. D. functional theory calculations and experiments suggested that the realization of the present reaction is due to a change in the regiodetermining step from commonly encountered irreversible C-H activations, which are reversible here, to an unexpected Pd migration process, which is regiodetermining. This is a new strategy to achieve γ-C-H activation, compared with the previous strategy, making γ-C-H activation both the turnover- and regiodetermining step.
ACS Catalysis published new progress about Alkylation catalysts, regioselective. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics