Nie, Li Fei published the artcileDesign, synthesis, and toward a side-ring optimization of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and their effect on melanin synthesis in murine B16 cells, Product Details of C7H6ClFO2S, the main research area is oxo tetrahydro pyrrolothienopyrimidinyl benzenesulfonamide preparation melanin synthesis activity; methyl oxo hexahydro thienopyrimidoazepinyl benzenesulfonamide preparation melanin synthesis activity.
The synthesis of 48 novel 3-sulfonylamides containing a tricyclic thieno[2,3-d]pyrimidin-4(3H)-one moiety, I [R1 = H, 3-F, 3-NO2, etc.; R2 = H, 4-Me, 5-Cl, etc.; n = 1,3], and their influence on melanin synthesis in murine B16 cells. All target sulfonylamides I were synthesized through key intermediate 3-nitro-thieno[2,3-d]pyrimidin-4(3H)-ones using three types of ipso-nitration reactions. In this case, the pyrido[1,2-a]- fragment of the thieno[2,3-d]pyrimidine moiety was converted to pyrrolo[1,2-a]- and azepino[1,2-a]- side-rings in order to evaluate the bioactivities of the synthesized derivatives for a structure activity-relationships point of view. The obtained results suggested that some of the selected compounds revealed a promising influence on melanin synthesis in murine B16 cells and may serve as lead compounds for further drug discovery and development.
Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Product Details of C7H6ClFO2S.
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